低分子肝素联合复方氨基酸和硫酸镁治疗在胎儿生长受限孕妇中的应用  

Application of Low Molecular Weight Heparin Combined with Compound Amino Acids and Magnesium Sulfate in Pregnant Women with Fetal Growth Restriction

作　　者：林远霞 LIN Yuanxia(Shishi Maternal and Child Health Hospital,Shishi 362700,China)

机构地区：[1]石狮市妇幼保健院,福建石狮362700

出　　处：《中外医学研究》2025年第5期137-140,共4页CHINESE AND FOREIGN MEDICAL RESEARCH

摘　　要：目的:评估低分子肝素联合复方氨基酸和硫酸镁治疗在改善胎儿生长受限(FGR)孕妇中的临床效果。方法:选取2020年12月—2023年12月石狮市妇幼保健院接收的102例胎儿生长受限孕妇为研究对象。采用摸球法分组,奇数为对照组(n=51),偶数为观察组(n=51)。对照组孕妇接受复方氨基酸联合硫酸镁治疗,观察组孕妇在对照组基础上接受低分子肝素治疗。比较两组治疗前、治疗1周后胎儿发育情况[股骨长、双顶径、腹围、头围]、胎儿脐血流指数[胎儿脐动脉阻力指数(RI)、搏动指数(PI)、收缩期与舒张期流速比(S/D)、舒张末期血流速度(EDV)]、孕妇血液流变学[全血高切黏度(WBHSV)、全血低切黏度(WBLSV)、血浆黏度(BV)、血细胞比容(HCT)]。结果:治疗1周后,两组胎儿股骨长、双顶径、腹围、头围较治疗前均增长,且观察组长于对照组,差异有统计学意义(P<0.05)。治疗1周后,两组胎儿RI、PI、S/D较治疗前均下降,且观察组低于对照组,EDV较治疗前升高,且观察组高于对照组,差异有统计学意义(P<0.05)。治疗1周后,两组孕妇WBHSV、WBLSV、BV、HCT较治疗前下降,且观察组低于对照组,差异有统计学意义(P<0.05)。结论:低分子肝素联合复方氨基酸和硫酸镁治疗可显著改善胎儿生长受限孕妇的胎儿发育指标和脐血流参数,对母婴健康具有积极影响。Objective:To evaluate the clinical efficacy of Low Molecular Weight Heparin combined with Compound Amino Acid and Magnesium Sulfate in pregnant women with fetal growth restriction(FGR).Method:A total of 102 pregnant women with FGR were included from Shishi Maternal and Child Health Hospital from December 2020 to December 2023 were selected as the study subjects.The groups were divided by touch ball method,with odd numbers as control group(n=51)and even numbers as observation group(n=51).The pregnant women in the control group were treated with Compound Amino Acid combined with Magnesium Sulfate,and the pregnant women in the observation group were treated with Low Molecular Weight Heparin on the basis of the control group.Fetal development[femur length,biparietal diameter,abdominal circumference,head circumference],fetal umbilical blood flow indexes[fetal umbilical artery resistance index(RI),pulse index(PI),systolic-todiastolic velocity ratio(S/D),end diastolic velocity(EDV)],maternal hemorheology[whole blood high shear viscosity(WBHSV),whole blood low shear viscosity(WBLSV),blood plasma viscosity(BV),hematocrit(HCT)]before treatment and 1 week after treatment were compared between the two groups.Result:After 1 week of treatment,the femur length,biparietal diameter,abdominal circumference and head circumference of the fetus in the two groups increased compared with those before treatment,and the indexes in the observation group were longer than those of the control group,the differences were statistically significant(P<0.05).After 1 week of treatment,the fetal RI,PI and S/D in both groups decreased compared with those before treatment,and the indexes in the observation group were lower than those in the control group,and the EDV in both groups increased compared with those before treatment,and the index in the observation group was higher than that in the control group,and the differences were statistically significant(P<0.05).After 1 week of treatment,WBHSV,WBLSV,BV and HCT of pregnant women in the two groups we

关 键 词：低分子肝素 复方氨基酸 硫酸镁 胎儿生长受限 胎儿脐血流指数 

分 类 号：R71[医药卫生—妇产科学]