人绒毛膜促性腺激素信号转导和生物学活性测定研究进展  

Research progress on human chorinonic gonadotropin

作　　者：黄盈 梁成罡[2] HUANG Ying;LIANG Cheng-gang(GBA Center for Medical Device Evaluation and Inspection,NMPA,Shenzhen 518045,China;National Institutes for Food and Drug Control,State Key Laboratory of Drug Regulatory Science,Beijing 102629,China)

机构地区：[1]国家药品监督管理局药品审评检查大湾区分中心,深圳518045 [2]中国食品药品检定研究院药品监管科学全国重点实验室,北京102629

出　　处：《药物分析杂志》2025年第1期51-58,共8页Chinese Journal of Pharmaceutical Analysis

摘　　要：人绒毛膜促性腺激素(hCG)是人体生殖和代谢过程的重要调节因子。hCG可以用于辅助生殖和治疗不孕不育症,还能用于治疗性机能障碍,如阳痿、隐睾以及侏儒症等,作为内分泌系统药物发挥着不可替代的作用。本文简述了hCG的应用、分子结构、受体结构、信号通路和生物活性检测方法等内容。此外,对hCG药物的发展和生物活性检测方法提出了展望。Human chorinonic gonadotropin(hCG)is an important regulator of reproductive and metabolic processes in the human body.hCG can be used for assisted reproduction and treatment of infertility.It is also used to treat sexual dysfunctions such as impotence,cryptorchidism,and dwarfism.hCG plays an irreplaceable role as an endocrine system drug.This article briefly describes the applications,molecular structure,receptor structure,signaling pathways and bioactivity assays of hCG.In addition,an outlook on the development of hCG drugs and bioactivity detection menthods is presented.

关 键 词：人绒毛膜促性腺激素 糖蛋白激素 结构 受体 信号通路 生物活性 报告基因 

分 类 号：R917[医药卫生—药物分析学]