夏桑菊核桃灸凝胶眼贴的制备工艺研究  

Study on Preparation of Xiasangju Walnut Moxibustion Eye-Cataplasm(夏桑菊核桃灸凝胶眼贴)

作　　者：杨静琦[1] 许保海[1] 张静[1] 姜洋[1] 侍方[1] YANG Jingqi;XU Baohai;ZHANG Jing;JIANG Yang;SHI Fang(Beijing Jishuitan Hospital,Capital Medical University,Beijing 100035,China)

机构地区：[1]首都医科大学附属北京积水潭医院,北京100035

出　　处：《中医药导报》2025年第2期57-60,70,共5页Guiding Journal of Traditional Chinese Medicine and Pharmacy

基　　金：全国中药特色技术传承人才培训项目(T20194828003);北京市医院管理中心科研培育项目(PZ2017011)。

摘　　要：目的:对夏桑菊核桃灸的灸粉进行剂型改良,将其改制为夏桑菊核桃灸凝胶眼贴,确定最佳制备工艺。方法:在物料用量考察单因素实验基础上,以综合感官、初黏力和持黏力为评价指标,采用L9(34)正交试验法优化聚丙烯酸钠(NP-700)、羧甲基纤维素钠(CMC-Na)、甘羟铝、酒石酸的用量。结果:优选出最佳物料处方为夏桑菊药粉1.500 g、NP-7000.400 g、CMC-Na 0.400 g、甘羟铝0.015 g、甘油5.000 g、蒸馏水4.000 g、酒石酸0.020 g,最佳搅拌时间为30 min,最佳搅拌温度为20~40℃。结论:该制备工艺简便稳定可行,所制备的夏桑菊核桃灸凝胶眼贴性能良好,适合制剂开发生产。Objective:To reform the dosage form of Xiasangju walnut moxibustion powder,change it into Xiasangju walnut moxibustion eye-cataplasm,and determine the best preparation process.Methods:Based on the single factor experiment of material usage inspection,the amount of sodium polyacrylate(NP-700),sodium carboxymethyl cellulose(CMC-Na),aluminum glycyrrhizinate and tartaric acid are optimized by L9(34)orthogonal experiment with comprehensive sensory,initial viscosity and viscosity as evaluation indexes.Results:The best prescription is Xiasangju medicine powder 1.500 g,NP-7000.400 g,CMC-Na 0.400 g,aluminum glycyrrhizinate 0.015 g,glycerin 5.000 g,distilled water 4.000 g,and tartaric acid 0.020 g.The best stirring time is 30 min,and the best stirring temperature is 20~40℃.Conclusion:The preparation process is simple,stable and feasible.The prepared Xiasangju walnut moxibustion eye-cataplasm has good performance and it is suitable for the development and production of preparations.

关 键 词：夏桑菊 核桃灸 凝胶贴膏 基质优化 制备工艺 单因素实验 正交试验 

分 类 号：R283.6[医药卫生—中药学]