活血救心丹治疗永久性心房颤动(气虚血瘀证)的临床疗效及其对血清GDF-15、vWF的影响  

Clinical Observation of Huoxue Jiuxin Mini-pill(活血救心丹)On Permanent Atrial Fibrillation(Qi-Deficiency and Blood-Stasis Type)and Its Effect on Serum GDF-15 and vWF

作　　者：王馨 马俊 夏洁 魏鹂蔓 魏玉洁 WANG Xin;MA Jun;XIA Jie;WEI Liman;WEI Yujie(First Clinical Medical College,Shandong University of Traditional Chinese Medicine,Ji'nan Shandong 250355,China;Yantai Traditional Chinese Medicine Hospital,Yantai Shandong 264013,China)

机构地区：[1]山东中医药大学第一临床医学院,山东济南250355 [2]烟台市中医医院,山东烟台264013

出　　处：《中医药导报》2025年第2期75-80,共6页Guiding Journal of Traditional Chinese Medicine and Pharmacy

基　　金：山东省中医药科技项目(Z-2023056T)。

摘　　要：目的:观察活血救心丹治疗永久性心房颤动(气虚血瘀证)的临床疗效及其对血清生长分化因子(GDF-15)、血管性血友病因子(vWF)的影响。方法:纳入永久性心房颤动气虚血瘀证患者100例,随机分为对照组和观察组,每组50例。对照组患者采用常规的西医治疗,观察组患者在对照组基础上,加用活血救心丹,两组患者治疗周期均为12周。记录并观察两组患者治疗前后中医证候积分、血清GDF-15、血浆D-二聚体(DD)、血清vWF、凝血功能及生活质量评分,统计出血性事件发生人数,并评估临床疗效。结果:治疗后,两组患者生活质量评分均较治疗前升高(P<0.05),且观察组的总有效率、生活质量评分和满意度均高于对照组(P<0.05)。与治疗前比较,两组患者治疗后部分活化凝血活酶时间(APTT)和血浆凝血酶原时间(PT)水平均提高(P<0.05),且观察组患者治疗后APTT和PT水平高于对照组(P<0.05);两组患者治疗后纤维蛋白原(FIB)浓度均下降(P<0.05),且观察组患者治疗后FIB浓度低于对照组(P<0.05);两组患者治疗后血浆D-二聚体、血清GDF-15、vWF水平均较治疗前降低(P<0.05),且观察组患者血浆D-二聚体、血清GDF-15、vWF低于对照组(P<0.05)。两组患者出血性事件的发生情况比较,差异无统计学意义(P<0.05)。结论:活血救心丹联合常规西药治疗永久性心房颤动(气虚血瘀型)患者,能提高临床疗效,预防血栓形成,提升患者的生存质量。同时,该药物能够显著降低患者血清中的GDF-15和vWF水平,减少心肌损伤及炎症反应,整体安全性良好。Objective:To observe the clinical effect of Huoxue Jiuxin Mini-pill on permanent atrial fibrillation(Qi-deficiency and blood-stasis type)and its effect on serum growth differentiation factor(GDF-15)and von Willebrand factor(vWF).Methods:A total of 100 patients with permanent atrial fibrillation of Qi-deficiency and blood-stasis type were randomly divided into control group and observation group,with 50 cases in each group.The control group was treated with conventional Western medicine,and the observation group was treated with Huoxue Jiuxin Mini-pill on the basis of the control group.The treatment cycle of both groups was 12 weeks.TCM symptom scores,serum GDF-15,plasma D-dimer(DD),serum vWF,coagulation function,and quality of life scores of the two groups were observed before and after treatment,the number of hemorrhagic events were recorded,so as to evaluate the clinical efficacy of Huoxue Jiuxin Mini-pill on permanent atrial fibrillation(Qi-deficiency and blood-stasis type).Results:After treatment,the scores of quality of life in both groups were higher than before(P<0.05),and the total effective rate,scores of quality of life and satisfaction in observation group were higher than those in control group(P<0.05).Compared with before treatment,the levels of partial activated partial thromboplastin time(APTT)and prothrombin time(PT)in 2 groups were increased(P<0.05),and the levels of APTT and PT in observation group were higher than those in control group(P<0.05).Fibrinogen(FIB)concentration decreased in both groups(P<0.05),and the observation group was lower than that in control group(P<0.05).After treatment,the levels of plasma D-dimer,serum GDF-15,and vWF in both groups of patients decreased compared to before treatment(P<0.05),and the plasma D-dimer,serum GDF-15,and vWF levels in the observation group were lower than those in the control group(P<0.05).There was no statistically significant difference in the occurrence of hemorrhagic events among the group of patients(P<0.05).Conclusion:The combination of Huox

关 键 词：永久性房颤 气虚血瘀证 活血救心丹 血清GDF-15 血清vWF 

分 类 号：R256.22[医药卫生—中医内科学]