中药活性成分调控MAPK信号通路抗肝纤维化的研究进展  

Research progress on the active ingredients of traditional Chinese medicine against hepatic fibrosis by regulating the MAPK signaling pathway

作　　者：黄甫静 谢星星 刘学 范玲 余志刚[1] 张金娟 HUANG Fujing;XIE Xingxing;LIU Xue;FAN Ling;YU Zhigang;ZHANG Jinjuan(Department of Pharmacy,Ya'an People's Hospital,Sichuan Ya'an 625000,China;School of Basic Medicine,Guizhou Medicine University,Guizhou Guiyang 550000,China)

机构地区：[1]雅安市人民医院药剂科,四川雅安625000 [2]贵州医科大学基础医学院,贵州贵阳550000

出　　处：《中国医院药学杂志》2025年第2期225-233,共9页Chinese Journal of Hospital Pharmacy

基　　金：四川省科技厅科技计划苗子工程重点项目(编号:2022JDRC0146);雅安市重点科技计划应用技术研究与开发面上项目(编号:22KJJH0039)。

摘　　要：肝纤维化(hepatic fibrosis,HF)是多种慢性肝病发展的可逆性病理过程。若不能及时有效地治疗,HF将会进展至肝硬化、肝癌等恶性病理阶段,严重影响患者的生命健康和生活质量。现有的HF临床治疗手段效果有限,因此,寻找新型抗HF药物或活性成分已成为临床的迫切需求。丝裂原活化蛋白激酶(mitogen-activated protein kinase,MAPK)信号通路在细胞增殖、分化和凋亡等方面具有重要的调节作用,也是调控HF发生发展的关键靶点之一。研究证实,通过中药活性成分干预MAPK信号通路的激活,对于抗HF具有积极作用。该文对MAPK信号通路调控HF的作用机制及中药活性成分基于该通路治疗HF的研究进行综述,以期为今后抗肝纤维化的新药研发提供思路。Hepatic fibrosis(HF) is a reversible pathological process associated with various chronic liver diseases.If left untreated,it can progress to severe pathological stages like cirrhosis and liver cancer,significantly impacting the health and quality of life.Currently,available clinical treatments for HF demonstrate limited efficacy,highlighting the urgent need for new drugs or active ingredients against HF.The mitogen-activated protein kinase(MAPK) signaling pathway plays a crucial regulatory role in cell proliferation,differentiation,and apoptosis,making it a key target in the modulation of HF development.Research has shown that interfering with the activation of MAPK signaling pathways through active ingredients of traditional Chinese medicine(TCM) herbals can yield positive outcomes in combating HF.This review examined the role of the MAPK signaling pathway in regulating HF and explored the therapeutic potential of active ingredients of TCM herbals targeting this pathway.Our aim is to provide insights that may contribute to the future development of novel drugs against HF.

关 键 词：肝纤维化 MAPK信号通路 中药活性成分 研究进展 

分 类 号：R285[医药卫生—中药学] R975[医药卫生—中医学]