弧形变截面微通道内颗粒富集的实验研究  

Experimental Study on Particle Enrichment in Arc-Shaped Variable Cross-Section Microchannels

作　　者：董骅 黄龙润 范亮亮 赵亮[1] DONG Hua;HUANG Longrun;FAN Liangliang;ZHAO Liang(State Key Laboratory of Multiphase Flow in Power Engineering,Xi'an Jiaotong University,Xi'an 710049,China;School of Mechanical Engineering,Xi'an Jiaotong University,Xi'an 710049,China)

机构地区：[1]西安交通大学,动力工程多相流多相流国家重点实验室,西安710049 [2]西安交通大学机械工程学院,西安710049

出　　处：《工程热物理学报》2025年第2期486-490,共5页Journal of Engineering Thermophysics

基　　金：国家自然科学基金面上项目(No.52076174)。

摘　　要：微通道内的微颗粒高效富集在生物医学等领域有着重要的应用价值,如对血液中的目标细胞进行高效富集,有助于提高微流控芯片技术检测的准确度。弧形微通道因其能够引发迪安拖曳力,是实现微颗粒运动操控的一种有效方式。弧形微通道牛顿流体中,微颗粒主要受到惯性升力和迪安拖曳力的共同作用而富集在弧形微通道中的特定平衡位置。有效调控微颗粒在微通道中的富集位置,对于后续的高效精确检测有着重要的意义。本文通过在弧形微通道中引入一系列的尖角微结构,改变颗粒在微通道中的受力,最终实现对颗粒富集位置的有效调控。研究发现尖角结构位置及流动参数对颗粒的平衡位置有着重要的影响,颗粒的平衡位置会向尖角结构侧偏离。The efficient enrichment of microparticles in microchannels has significant application value in fields such as biomedicine.For example,the efficient enrichment of target cells in blood can help improve the accuracy of microfluidic chip technology detection.Arc-shaped microchannels are an effective way to manipulate the motion of microparticles due to their ability to induce Dean drag forces.In the Newtonian fluid of arc-shaped microchannels,microparticles are mainly enriched at specific equilibrium positions in the microchannels due to the combined action of inertial lift forces and Dean drag forces.Effectively controlling the enrichment position of microparticles in microchannels is crucial for subsequent efficient and accurate detection.In this study,a series of sharp-angled microstructures were introduced in the arc-shaped microchannels to change the forces acting on the particles,ultimately achieving effective control of particle enrichment positions.The research found that the position of the sharp-angled structures and flow parameters have a significant impact on the equilibrium position of the particles,causing the particles'equilibrium position to deviate towards the side of the sharp-angled structures.

关 键 词：弯曲通道 惯性富集 微流控 微流体 

分 类 号：TK123[动力工程及工程热物理—工程热物理]