基于“肝主疏泄”理论探讨肠道菌群对绝经后骨质疏松症的影响  

Exploring Effect of Intestinal Flora on Postmenopausal Osteoporosis Based on Theory of"Liver Governing Catharsis"

作　　者：李炎亮 陈明[1] 任君辉 刘洪 庄伟[1] LI Yanliang;CHEN Ming;REN Junhui;LIU Hong;ZHUANG Wei(Department of Orthopedics,Jiangnan Hospital Affiliated to Zhejiang Chinese Medical University/Hangzhou Xiaoshan District Traditional Chinese Medicine Hospital,Hangzhou 311201,China;Zhejiang Chinese Medical University,Hangzhou 310053,China)

机构地区：[1]浙江中医药大学附属江南医院杭州市萧山区中医院骨伤科,杭州311201 [2]浙江中医药大学,杭州310053

出　　处：《医学综述》2025年第6期701-705,共5页Medical Recapitulate

基　　金：国家中医药管理局科技司-浙江省中医药管理局共建科技计划项目(20231000416);浙江省中医药科技计划(2024ZL783);杭州市生物医药和健康产业发展扶持科技专项(2023WJC236)。

摘　　要：绝经后骨质疏松症(PMOP)是绝经后女性常见的疾病之一,严重影响患者生活质量。目前西医治疗PMOP存在较多的并发症,中医药在治疗PMOP上具有一定优势。而中医论治PMOP多从肾出发,也存在一定的局限性。女子以肝为先天,因此从肝论治PMOP存在其必要性。结合其临床特点,从调节肠道菌群层面探讨“肝主疏泄”理论在PMOP患者诊疗中的作用,可为该疾病诊治提供新思路。未来,应更加注重“肝主疏泄”理论在PMOP患者中的应用,以提高PMOP的临床诊疗效果。Postmenopausal osteoporosis(PMOP)is one of the common diseases in postmenopausal women,which seriously affects the quality of life of the patients.At present,there are many complications in the treatment of PMOP by western medicine,and Chinese medicine has certain advantages in the treatment of PMOP.Chinese medicine treats PMOP mostly from the kidney,which also has some limitations.As the liver is the innate part especially important for women,it is necessary to treat PMOP from the liver perspective.Taking into account the clinical characteristics of PMOP,we discuss the role of the theory that the"liver governing catharsis"in the diagnosis and treatment of PMOP from the level of regulating the intestinal flora,which will provide a new way of thinking for the diagnosis and treatment of this disease.In the future,more attention should be paid to applying the theory of"liver governing catharsis"in patients with PMOP,so as to improve the clinical diagnosis and treatment effect.

关 键 词：绝经后骨质疏松症 肝主疏泄 肠道菌群紊乱 

分 类 号：R274.9[医药卫生—中西医结合]