低级别细胞学异常患者宫颈病变风险预测方法及进展  

Methods and Advances in Predicting Risk of Cervical Lesions in Patients with Low-grade Cytological Abnormalities

作　　者：陈力畅 唐伊蔓 陈思思 金海红[2] CHEN Lichang;TANG Yiman;CHEN Sisi;JIN Haihong(Hebei North College,Zhangjiakou 075000,China;Department of Gynecology,the First Hospital of Qinhuangdao,Qinhuangdao 066000,China)

机构地区：[1]河北北方学院,河北张家口075000 [2]秦皇岛市第一医院妇科,河北秦皇岛066000

出　　处：《医学综述》2025年第6期740-745,共6页Medical Recapitulate

基　　金：河北省重点研发计划项目卫生健康创新专项(21377708D)。

摘　　要：宫颈癌是女性生殖系统常见肿瘤,对女性健康构成严重威胁。其病因明确,早期筛查有助于及时诊断和治疗。液基薄层细胞学检查已在全球各国宫颈癌筛查中得到验证,具有特异度高的优势,但也存在一定局限性。为了提高宫颈癌的筛查效率,对于低级别细胞学异常的患者,可以采用人乳头瘤病毒检测、阴道镜检查和新型生物标志物检查等分流手段进一步评估宫颈病变的风险。这些分流方式能有效提升宫颈癌及癌前病变的分级和诊断,同时构建宫颈癌综合防治模式,为实现消除子宫颈癌的战略目标提供支持。Cervical cancer is a common tumor in the female reproductive system and poses a serious threat to women′s health.The cause is clear,and early screening helps to diagnose and treat in a timely manner.Liquid-based thin-layer cytological testing has been verified in cervical cancer screening in countries around the world,which has the advantage of high specificity,but also certain limitations.In order to improve the screening efficiency of cervical cancer,for patients with low-grade cytological abnormalities,human papillomavirus detection,colposcopy and novel biomarker examinations can be used to further assess the risk of cervical lesions.These triage methods can effectively improve the grading and diagnosis of cervical cancer and precancerous lesions,while building a comprehensive prevention and treatment model for cervical cancer,providing support for realization of the strategic goal of eliminating cervical cancer.

关 键 词：未明确诊断意义的非典型鳞状细胞 低级别鳞状上皮内病变 宫颈上皮内瘤变 宫颈癌筛查 分流 

分 类 号：R711.74[医药卫生—妇产科学]