基于数据挖掘的某院中药治疗慢性肾脏病的用药规律和用药安全性分析  

Medication Rules and Safety of Traditional Chinese Medicine in the Treatment of Chronic Kidney Disease in A Hospital Based on Data Mining

作　　者：张婧[1] 王景红[1] 张冰[2] 林志健[2] 吴佳妮 张瑞丽[1] 张梅竹 ZHANG Jing;WANG Jinghong;ZHANG Bing;LIN Zhijian;WU Jiani;ZHANG Ruili;ZHANG Meizhu(Dept.of Pharmacy,Wangjing Hospital,China Academy of Chinese Medical Sciences,Beijing 100102,China;School of Chinese Materia Medica,Beijing University of Chinese Medicine,Beijing 102488,China)

机构地区：[1]中国中医科学院望京医院药学部,北京100102 [2]北京中医药大学中药学院,北京102488

出　　处：《中国医院用药评价与分析》2025年第2期148-152,共5页Evaluation and Analysis of Drug-use in Hospitals of China

基　　金：全国中药特色技术传承人才培训项目(No.国中医药人教函〔2023〕96号);北京市药学会课题(No.zy2020-18)。

摘　　要：目的:基于数据挖掘的方法,探讨该院中药治疗慢性肾脏病(CKD)的用药规律和用药安全性。方法:建立该院CKD患者中药饮片数据库,利用古今医案云平台进行统计分析、关联性分析、社团分析和聚类分析。结果:本研究共收集该院肾病科中药处方52133张,纳入CKD患者处方4225张,建立CKD患者中药处方数据库。4225张处方中,涉及中药380味,累计使用频次74740次。黄芪、丹参和大黄等23味中药为高频使用药物;涉及半夏、附子和全蝎等7个有毒中药。核心药物组成为“丹参-黄芪-大黄”。对排序居前10位的高频药物进行聚类分析,可将其分为“黄芪、丹参”“茯苓、大黄”和“赤芍、荆芥、柴胡、麦芽、槐花和地黄”3组。高频药物和有毒中药均存在超《中华人民共和国药典:一部》(2020年版)限量使用情况。结论:应加强中药饮片使用监护,重视有毒及含毒性成分中药饮片的用药安全,为CKD患者的临床中药学服务提供参考。OBJECTIVE:To probe into the medication rules and safety of traditional Chinese medicine in the treatment of chronic kidney disease(CKD)based on data mining in a hospital.METHODS:The database of traditional Chinese medicine decoction pieces for patients with CKD in the hospital was established,and statistical analysis,association analysis,community analysis and cluster analysis were carried out by the cloud platform of ancient and modern medical records.RESULTS:A total of 52133 traditional Chinese medicine prescriptions were collected from the Nephrology department of the hospital,including 4225 prescriptions for patients with CKD,and the traditional Chinese medicine prescription database for patients with CKD was established.Among the 4225 prescriptions,380 kinds of traditional Chinese medicine were included,and the cumulative frequency was 74740 times.Totally 23 kinds of traditional Chinese medicine such as Hedysarum multijugum maxim,Radix Salviae,and Radix Rhei Et Rhizome were frequently used,involving 7 toxic traditional Chinese medicine drugs including Arum ternatum thunb,Aconiti lateralis radix praeparata and scorpioand.The core drug composition was“Radix Salviae-Hedysarum multijugum maxim-Radix Rhei Et Rhizome”.By cluster analysis,the top 10 high-frequency drugs could be divided into three groups,“Hedysarum multijugum maxim,Radix Salviae”,“Poria Cocos,Radix Rhei Et Rhizome”and“Radix paeoniae rubra,Schizonepetae herba,Radix bupleuri,Hordei fructus germinatus,Sophora japonica and Rehmanniae radix praeparata”.Both high-frequency drugs and toxic traditional Chinese medicine drugs had off-label drug use of the Pharmacopoeia of the People’s Republic of China(Part 1,2020 edition).CONCLUSIONS:It is necessary to strengthen the monitoring of the use of traditional Chinese medicine decoction pieces and the monitoring of adverse reactions in patients with CKD,and pay attention to the safety of the use of traditional Chinese medicine decoction pieces with toxic and toxic components,pay attention to the

关 键 词：慢性肾脏病 用药规律 用药安全 临床中药学 

分 类 号：R932[医药卫生—生药学]