扶元复衡汤加减联合TP化疗方案对宫颈癌癌因性疲乏患者疗效、抗肿瘤免疫应答、血清SCCA和CA199的影响  

Effects of Modified Fuyuan Fuheng Decoction Combined with TP Chemotherapy on Efficacy,Anti-Tumor Immune Response,Serum SCCA and CA199 in Patients with Cervical Cancer-Related Fatigue

作　　者：任梅梅[1] 刘宝刚[1] 李磊强 张梦馨[1] REN Meimei;LIU Baogang;LI Leiqiang;ZHANG Mengxin(The First Dept.of Oncology,the Second Affiliated Hospital of Shaanxi University of Chinese Medicine,Xi’an 712000,China)

机构地区：[1]陕西中医药大学第二附属医院肿瘤一科,西安712000

出　　处：《中国医院用药评价与分析》2025年第2期161-164,共4页Evaluation and Analysis of Drug-use in Hospitals of China

基　　金：陕西省自然科学基础研究计划项目(No.2022JM-126)。

摘　　要：目的:探讨扶元复衡汤加减联合TP化疗方案(紫杉醇+顺铂)对宫颈癌癌因性疲乏患者疗效、抗肿瘤免疫应答、血清鳞状细胞癌抗原(SCCA)和糖类抗原199(CA199)的影响。方法:选取2023年该院收治的宫颈癌癌因性疲乏患者98例,采用随机数字表法分为研究组和对照组,各49例。对照组患者采用TP化疗方案治疗,研究组患者采用扶元复衡汤联合TP化疗方案治疗,两组患者的疗程均为3个月。疗程结束后,比较两组患者的肿瘤控制率、中医症状评分、肿瘤相关抗原含量、抗肿瘤免疫应答水平、癌症疲乏量表(CFS)评分和不良反应。结果:研究组患者的肿瘤控制率为63.27%(31/49),显著高于对照组的40.82%(20/49),差异有统计学意义(P<0.05)。治疗后,研究组患者的CFS评分、各项中医症状评分,血清SCCA、CA199含量,血清白细胞介素(IL)-4、IL-5和IL-10含量低于对照组,血清γ干扰素、IL-2含量高于对照组,差异均有统计学意义(P<0.05)。研究组患者的不良反应发生率为12.24%(6/49),与对照组的14.29%(7/49)相比,差异无统计学意义(P>0.05)。结论:扶元复衡汤加减联合TP化疗方案对宫颈癌患者的肿瘤控制效果较好,可降低肿瘤标志物含量,有效缓解癌因性疲乏,改善机体细胞免疫平衡,抑制肿瘤细胞增殖,优化机体的抗肿瘤免疫应答。OBJECTIVE:To probe into the effects of modified Fuyuan Fuheng decoction combined with TP chemotherapy(taxol+carplatin)on efficacy,anti-tumor immune response,serum SCCA and CA199 in patients with cervical cancer-related fatigue.METHODS:A total of 98 patients with cervical cancer-related fatigue admitted into the hospital in 2023 were divided into the study group and control group by random number table method,with 49 cases in each group.The control group was treated with TP chemotherapy regimen,while the observation group received Fuyuan Fuheng decoction combined with TP chemotherapy regimen.The treatment course for both groups was 3 months.After treatment,the tumor control rate,traditional Chinese medicine symptom score,tumor-related antigen content,anti-tumor immune response level,cancer fatigue scale(CFS)score and adverse drug reactions were compared between two groups.RESULTS:The tumor control rate of the study group was 63.27%(31/49),significantly higher than that 40.82%(20/49)of the control group,the difference was statistically significant(P<0.05).After treatment,CFS score,traditional Chinese medicine symptom score,serum SCCA,CA199 contents,serum IL-4,IL-5 and IL-10 contents of the study group were lower than those of the control group,the serum IFN-γand IL-2 contents were higher than those of the control group,with statistically significant differences(P<0.05).The incidence of adverse drug reactions in the study group was 12.24%(6/49),compared with 14.29%(7/49)in the control group,the difference was not statistically significant(P>0.05).CONCLUSIONS:Modified Fuyuan Fuheng decoction combined with TP chemotherapy has significant tumor control effect on cervical cancer patients,which can decrease the tumor marker content,effectively alleviate the cancer-related fatigue,improve the cellular immune balance,inhibit the tumor cell proliferation,and optimize the anti-tumor immune response.

关 键 词：宫颈癌 癌因性疲乏 化疗 扶元复衡汤 抗肿瘤免疫应答 肿瘤标志物 

分 类 号：R932[医药卫生—生药学] R979.1[医药卫生—药学]