复方苦参注射液联合mFOLFOX6化疗方案对湿热蕴结型结肠癌患者细胞免疫功能及肠道菌群的影响  

Effects of Compound Kushen Injection Combined with mFOLFOX6 Chemotherapy on Cellular Immune Function and Intestinal Flora in Patients with Damp-Heat Accumulation Type Colon Cancer

作　　者：胡嘉芮 何薇薇[2] 王永霞 何晓华[1] 籍强[3] 渠少博 李占林[1] HU Jiarui;HE Weiwei;WANG Yongxia;HE Xiaohua;JI Qiang;QU Shaobo;LI Zhanlin(Dept.of Traditional Chinese Medicine,the First Affiliated Hospital of Hebei North University,Hebei Zhangjiakou 075061,China;Dept.of Stomatology,the First Affiliated Hospital of Hebei North University,Hebei Zhangjiakou 075061,China;Dept.of Cardiovascular Thoracic Surgery,the First Affiliated Hospital of Hebei North University,Hebei Zhangjiakou 075061,China)

机构地区：[1]河北北方学院附属第一医院中医科,河北张家口075061 [2]河北北方学院附属第一医院口腔内科,河北张家口075061 [3]河北北方学院附属第一医院胸心血管外科,河北张家口075061

出　　处：《中国医院用药评价与分析》2025年第2期180-183,187,共5页Evaluation and Analysis of Drug-use in Hospitals of China

基　　金：国家中西医协同“旗舰”科室建设项目(No.冀中医药〔2024〕11号)。

摘　　要：目的:探讨复方苦参注射液联合mFOLFOX6化疗方案(奥沙利铂+5-氟尿嘧啶+亚叶酸钙)对湿热蕴结型结肠癌患者细胞免疫功能及肠道菌群的影响。方法:选取2022年3月至2024年1月该院收治的Ⅲ-Ⅳ期结肠癌患者100例,采用完全随机化方法分为观察组(复方苦参注射液联合mFOLFOX6化疗方案)和对照组(单纯mFOLFOX6化疗方案),每组50例。观察联合应用复方苦参注射液对湿热蕴结型结肠癌患者的临床疗效、中医证候评分、细胞免疫功能及肠道菌群的影响。结果:观察组患者的客观缓解率为44.00%(22/50),显著高于对照组的24.00%(12/50),差异有统计学意义(P<0.05)。治疗后,观察组患者中医证候评分改善优于对照组,差异有统计学意义(P<0.05)。细胞免疫功能方面,观察组患者的CD4^(+)、CD4^(+)/CD8^(+)水平显著高于对照组,CD8^(+)水平低于对照组,差异均有统计学意义(P<0.05)。肠道菌群分析显示,观察组患者双歧杆菌、乳酸杆菌数量显著高于对照组,而大肠杆菌数量则低于对照组,差异均有统计学意义(P<0.05)。观察组患者胃肠道反应、骨髓抑制发生率低于对照组,差异均有统计学意义(P<0.05)。结论:复方苦参注射液联合mFOLFOX6化疗方案可显著改善湿热蕴结型结肠癌患者的临床疗效、细胞免疫功能及肠道菌群状态。OBJECTIVE:To probe into the effects of compound Kushen injection combined with mFOLFOX6 chemotherapy(oxaliplatin+5-fluorouracil+calcium folinate)on the cellular immune function and intestinal flora in patients with damp-heat accumulation type colon cancer.METHODS:A total of 100 patients with stageⅢto IV damp-heat accumulation type colon cancer admitted into the hospital from Mar.2022 to Jan.2024 were selected to be divided into observation group(given compound Kushen injection combined with mFOLFOX6 chemotherapy)and control group(given mFOLFOX6 chemotherapy alone)via complete randomization method,with 50 cases in each group.The effects of combined application of compound Kushen injection on clinical efficacy,traditional Chinese medicine syndrome cores,cellular immune function and intestinal flora in patients with damp-heat accumulation type colon cancer were observed.RESULTS:The objective remission rate of the observation group was 44.00%(22/50),significantly higher than 24.00%(12/50)of the control group,with statistically significant difference(P<0.05).After treatment,the improvement of traditional Chinese medicine syndrome scores in the observation group was better than that in the control group,with statistically significant difference(P<0.05).In terms of the cellular immune function,the CD4^+(1)and CD4^+(1)/CD8^+(1)levels of the observation group were significantly higher than those of the control group,while the CD8^+(1)level was lower than that of the control group,with statistically significant differences(P<0.05).Intestinal flora analysis indicated that the numbers of Bifidobacterium and Lactobacillus were significantly higher and the number of Escherichia coli was lower in the observation group than those in the control group,with statistically significant differences(P<0.05).The incidences of gastrointestinal reaction and myelosuppression of the observation group were lower than those of the control group,with statistically significant differences(P<0.05).CONCLUSIONS:Compound Kushen injection combined

关 键 词：结肠癌 复方苦参注射液 细胞免疫功能 肠道菌群 

分 类 号：R979.1[医药卫生—药品] R932[医药卫生—药学]