芪蛭三七汤联合美托洛尔对冠心病稳定型心绞痛患者的疗效观察  

Effects of Qizhi Sanqi decoction combined with metoprolol on patients with stable angina pectoris caused by coronary heart disease

作　　者：赵建勋 Zhao Jianxun(Department of Pharmacy,Pinglu County People′s Hospital,Pinglu,Shanxi 044300,China)

机构地区：[1]平陆县人民医院药剂科,山西平陆044300

出　　处：《中国药物与临床》2025年第4期212-216,共5页Chinese Remedies & Clinics

摘　　要：目的研究芪蛭三七汤联合美托洛尔对冠心病稳定型心绞痛患者的疗效。方法选择2021年3月至2024年4月山西省平陆县人民医院的74例冠心病稳定型心绞痛患者,按照不同治疗方法分为2组。对照组采用美托洛尔,观察组采用芪蛭三七汤联合美托洛尔。比较2组的疗效、症状评分、血液流变学[红细胞比容(HCT)、纤维蛋白原(FG)、血小板黏附率(PAdR)、血小板聚集率(PAR)和全血高切黏度(HSV)]、心功能[每搏输出量(SV)、左心室舒张末期血容量(EDV)、心输出量(CO)、射血分数(EF)]和不良反应。结果观察组的有效率高于对照组(P<0.05)。治疗后,观察组的胸痛评分为(1.34±0.15)分、心悸评分为(1.02±0.19)分、下肢水肿评分为(0.87±0.13)分、胸闷气短评分为(1.25±0.29)分、神倦乏力评分为(1.09±0.14)分,低于对照组的(1.78±0.26)、(1.45±0.27)、(1.35±0.29)、(1.73±0.24)、(1.67±0.23)分,差异有统计学意义(P<0.05)。治疗后,观察组的HCT、FG、PAdR、PAR和HSV分别为(39.4±1.2)%、(3.01±0.17)g/L、(40.2±2.5)%、(54.8±10.4)%、(4.1±0.6)mPa·s,低于对照组的(42.1±2.8)%、(3.49±0.27)g/L、(43.9±5.3)%、(60.1±10.1)%、(5.8±0.6)mPa·s(P<0.05)。治疗后,观察组的SV、LVFS、CO分别为(58.5±12.4)ml/m^(2)、(31.6±4.3)%、(4.6±0.4)L/m^(2),高于对照组的(50.4±10.4)ml/m^(2)、(26.3±3.7)%、(3.6±0.4)L/m^(2),观察组的IVSD为(10.2±0.7)mm,低于对照组的(11.3±1.4)mm(P<0.05)。2组的关节痛、恶心呕吐、皮疹和肝功能异常等不良反应发生率比较,差异无统计学意义(P>0.05)。结论芪蛭三七汤联合美托洛尔能明显减轻冠心病稳定型心绞痛患者的症状,改善血液流变学和心功能,疗效显著。Objective To investigate the effects of Qizhi Sanqi decoction combined with metoprolol on patients with stable angina pectoris caused by coronary heart disease.Methods A total of 74 patients with stable angina pectoris caused by coronary heart disease Pinglu County People′s Hospital from March 2021 to April 2024 were divided into a control group and an observation group.The control group received metoprolol,while the observation group received Qizhi Sanqi decoction combined with metoprolol.The efficacy,symptom scores,hemorheology[hematocrit(HCT),fibrinogen(FG),platelet adhesion rate(PAdR),platelet aggregation rate(PAR),and whole blood high shear viscosity(HSV)],cardiac function[stroke volume(SV),left ventricular end diastolic blood volume(EDV),cardiac output(CO),ejection fraction(EF)],and adverse reactions were compared between the two groups.Results The effective rate of the observation group was higher than the control group(P<0.05).After treatment,the chest pain,palpitations,lower limb edema,chest tightness,shortness of breath,and fatigue scores of the observation group were(1.34±0.15),(1.02±0.19),(0.87±0.13),(1.25±0.29),and(1.09±0.14)points,respectively,which were lower than those of the control group[(1.78±0.26),(1.45±0.27),(1.35±0.29),(1.73±0.24),and(1.67±0.23)points](P<0.05).After treatment,the HCT,FG,PAdR,PAR,and HSV in the observation group were(39.4±1.2)%,(3.01±0.17)g/L,(40.2±2.5)%,(54.8±10.4)%,and(4.1±0.6)mPa·s,respectively,lower than those in the control group[(42.1±2.8)%,(3.49±0.27)g/L,(43.9±5.3)%,(60.1±10.1)%,and(5.8±0.6)mPa·s](P<0.05).After treatment,the SV,LVFS,and CO of the observation group were(58.5±12.4)ml/m^(2),(31.6±4.3)%,and(4.6±0.4)L/m^(2),respectively,which were higher than those of the control group[(50.4±10.4)ml/m^(2),(26.3±3.7)%,and(3.6±0.4)L/m^(2)].The IVSD of the observation group was(10.2±0.7)mm,which was lower than that of the control group[(11.3±1.4)mm](P<0.05).There was no statistically significant difference in the incidence of adverse rections su

关 键 词：芪蛭三七汤 美托洛尔 心绞痛 稳定型 

分 类 号：R541.4[医药卫生—心血管疾病]