STE联合Ⅲ型前胶原N端肽、透明质酸指标评估慢性乙型肝炎患者肝纤维化程度的临床研究  

Clinical study of STE combined with type Ⅲ procollagen N-terminal peptide and hyaluronic acid index to assess the degree of liver fibrosis in patients with chronic hepatitis B

作　　者：何小亭 陈威 秦一男 潘洋 HE Xiaoting;CHEN Wei;QIN Yinan;PAN Yang(Department of Ultrasound,Huai'an Hospital Affiliated to Yangzhou University(The Fifth People's Hospital of Huai'an),Huai'an,Jiangsu 223300,China)

机构地区：[1]扬州大学附属淮安医院<淮安市第五人民医院>超声医学科,江苏淮安223300

出　　处：《影像研究与医学应用》2025年第3期16-18,共3页Journal of Imaging Research and Medical Applications

摘　　要：目的:探讨声触诊弹性成像(STE)联合Ⅲ型前胶原N端肽(PⅢNP)、透明质酸(HA)指标评估慢性乙型肝炎患者肝纤维化程度的价值。方法:选取2023年1月—12月淮安市第五人民医院收治的785例慢性乙型肝炎患者作为观察组,另选取同期健康体检者230名作为对照组,根据观察组患者肝纤维化程度不同将其分为S_(0)期(162例)、S_(1)期(160例)、S_(2)期(166例)、S_(3)期(155例)、S_(4)期(142例),均行STE检查,测量肝脏硬度值(LSM)。比较对照组与观察组的LSM、PⅢNP、HA水平,比较观察组不同纤维化程度患者的LSM、PⅢNP、HA水平。分析LSM、PⅢNP、HA与慢性乙型肝炎患者肝纤维化程度的相关性。结果:观察组各指标均高于对照组,差异有统计学意义(P<0.05)。与S_(0)期比,S_(1)期、S_(2)期、S_(3)期、S_(4)期LSM、PⅢNP、HA水平均更高,差异均有统计学意义(P<0.05),LSM、PⅢNP、HA水平与肝纤维化分期均呈正相关(P<0.05)。结论:慢性乙型肝炎患者LSM、PⅢNP、HA水平随着肝纤维化加重而升高,STE联合PⅢNP、HA有助于判断慢性乙型肝炎患者肝纤维化程度。Objective To investigate the value of sonic tactile elastography(STE)combined with type Ⅲ procollagen N-terminal peptide(PⅢNP)and hyaluronic acid(HA)in evaluating the degree of liver fibrosis in patients with chronic hepatitis B.Methods From January to December 2023,a total of 785 patients with chronic hepatitis B admitted to the Fifth People's Hospital of Huai'an were selected as the observation group.Additionally,a total of 230 healthy individuals undergoing physical examination during the same period were selected as the control group.The patients in the observation group were divided into different stages based on the degree of liver fibrosis:S_(0)stage(162 cases),S_(1)stage(160 cases),S_(2)stage(166 cases),S_(3)stage(155 cases),and S_(4)stage(142 cases).All participants underwent transient elastography(STE)examination to measure liver stiffness values(LSM).The LSM,PⅢNP,and HA levels were compared between the control group and the observation group,as well as among patients with different degrees of fibrosis in the observation group.The correlation between LSM,PⅢNP,HA,and the degree of liver fibrosis in patients with chronic hepatitis B was analyzed.Results The indicators in the observation group were all higher than those in the control group,and the differences were statistically significant(P<0.05).Compared with S_(0)stage,the levels of LSM,PⅢNP,and HA were higher in S_(1)stage,S_(2)stage,S_(3)stage,and S_(4)stage,and the differences were statistically significant within the five groups(P<0.05).The levels of LSM,PⅢNP,and HA were positively correlated with the stage of liver fibrosis(P<0.05).Conclusion The levels of LSM,PⅢNP and HA in patients with chronic hepatitis B increase with the aggravation of liver fibrosis,STE combined with PⅢNP,HA can help determine the degree and prognosis of liver fibrosis in patients with chronic hepatitis B.

关 键 词：慢性乙型肝炎 肝纤维化 声触诊弹性成像 Ⅲ型前胶原N端肽 透明质酸 

分 类 号：R445.1[医药卫生—影像医学与核医学]