高频超声弹性成像参数联合血清TgAb、sIL-2R水平检测对甲状腺结节性质的鉴别诊断价值  

Diagnostic value of high-frequency ultrasound elastography parameters combined with serum TgAb and sIL-2R levels for differential diagnosis of thyroid nodule properties

作　　者：姚娟 张悦 王燕铭 YAO Juan;ZHANG Yue;WANG Yanming(Department of Ultrasound Medicine,Zhoukou Orthopaedic Hospital,Zhoukou 466000,China;Department of Ultra-sound,Zhoukou Maternal and Child Health Hospital(Zhoukou Children's Hospital;Department of Ultrasound,South Tai-hu Hospital Affiliated to Huzhou University)

机构地区：[1]周口骨科医院超声医学科,河南周口466000 [2]周口市妇幼保健院(周口市儿童医院)超声科 [3]湖州学院附属南太湖医院超声科

出　　处：《沈阳医学院学报》2025年第1期43-47,共5页Journal of Shenyang Medical College

基　　金：河南省医学科技攻关联合共建项目(No.LHGJ20219451)。

摘　　要：目的:探讨高频超声弹性成像参数联合血清抗甲状腺球蛋白抗体(TgAb)、可溶性白介素-2受体(sIL-2R)水平检测对甲状腺结节性质的鉴别诊断价值。方法:回顾性分析2021年6月至2023年6月我院收治的83例甲状腺结节患者的临床资料,均行高频超声弹性成像检查,根据细针穿刺或术后病理结果,将患者分别纳入良性组(52例)与恶性组(31例)。比较2组影像学特征、高频超声弹性成像参数(弹性应变率、弹性评分)及血清TgAb、sIL-2R水平,分析联合应用对甲状腺恶性结节的诊断价值。结果:恶性组回声不均匀、形态不规则、伴穿支血管、边界不清晰及砂砾样钙化占比高于良性组(P<0.01);恶性组高频超声弹性成像参数弹性应变率、弹性评分及血清TgAb、sIL-2R水平均高于良性组(P<0.01);高频超声弹性成像参数弹性应变率、弹性评分及血清TgAb、sIL-2R联合诊断甲状腺恶性结节的AUC为0.931,敏感度为90.32%,特异度为82.69%,约登指数为0.730,优于各参数及血清指标单独诊断价值(P<0.05)。结论:高频超声弹性成像参数联合血清TgAb、sIL-2R水平对甲状腺结节性质具有一定鉴别诊断价值,可作为临床鉴别诊断结节性质的有效检查方案之一。Objective:To investigate the value of high frequency ultrasound elastic imaging parameters combined with serum anti-thyroglobulin antibody(TgAb)and soluble interleukin-2 receptor(sIL-2R)levels in differential diagnosis of thyroid nodule properties.Methods:A total of 83 patients with thyroid nodules admitted to our hospital from Jun 2021 to Jun 2023 were selected.All of them were examined by high-frequency ultrasound elastography.According to fine needle puncture or postoperative pathological results,the patients were included in the benign group(52 cases)and the malignant group(31 cases),respectively.The imaging characteristics,high-frequency ultrasound elastography parameters(elastic strain rate,elasticity score)and serum TgAb and sIL-2R levels of the 2 groups were compared,and the diagnostic value of the combined application for malignant thyroid nodules were analyzed.Results:The proportion of uneven echo,irregular morphology,perforating vessels,unclear boundaries,and gravel-like calcification in the malignant group was higher than that in the benign group(P<0.01).The elastic strain rate,elastic score,and serum TgAb and sIL-2R levels in the malignant group were higher than those in the benign group(P<0.01).The AUC of the combined diagnosis of thyroid malignant nodules with elastic strain rate,elastic score,and serum TgAb and sIL-2R was 0.931,with a sensitivity of 90.32%,a specificity of 82.69%,and a Youden index of 0.730,which were superior to the diagnostic value of each indicator alone(P<0.05).Conclusion:High frequency ultrasound elastic imaging parameters combined with serum TgAb and sIL-2R levels have a certain value in differential diagnosis of thyroid nodule properties,and can be used as one of the effective diagnostic methods for differential diagnosis of thyroid nodule properties.

关 键 词：高频超声弹性成像 抗甲状腺球蛋白抗体 可溶性白介素-2受体 甲状腺结节 鉴别诊断 

分 类 号：R445.1[医药卫生—影像医学与核医学] R581.3[医药卫生—诊断学]