区域性软脑膜侧支评分与动脉到达伪影评分评估患者脑功能状态的价值:基于3D TOF MRA与3D-ASL成像  

Evaluation value of regional leptomeningeal collateral and arterial transit artifact scores in assessing brain function status of patients:based on 3D TOF MRA and 3D-ASL imaging

作　　者：何艺琳 邓耿颖 何念慈 宋诗倩 陈伟[3] 张慧[2] HE Yilin;DENG Gengying;HE Nianci;SONG Shiqian;CHEN Wei;ZHANG Hui(School of Medical Imaging,Changsha Medical College,Changsha 410219,China;Department of Human Anatomy,Changsha Medical College,Changsha 410219,China;Department of Radiology,Xiangya Hospital,Central South University,Changsha 410008,China)

机构地区：[1]长沙医学院医学影像学院,湖南长沙410219 [2]长沙医学院人体解剖学教研室,湖南长沙410219 [3]中南大学湘雅医院放射科,湖南长沙410008

出　　处：《分子影像学杂志》2025年第2期191-196,共6页Journal of Molecular Imaging

基　　金：湖南省大学生创新创业训练计划(湘教通[2022]174号-一般项目-4629);湖南省线下一流本科课程(湘教通[2021]322号)。

摘　　要：目的探讨三维时间飞跃法磁共振血管成像(3D TOF MRA)下的区域性软脑膜侧支(rLMC)评分、三维动脉自旋标记(3DASL)成像序列下的动脉到达伪影(ATA)评分与脑功能受损情况的关系。方法回顾性分析2018年1月~2023年10月于中南大学湘雅医院行脑部T1WI、T2WI、T2 FLAIR、3D TOF MRA、3D-ASL检查的48例患者,根据rLMC评分和ATA评分对患者软脑膜侧支状态进行评估,采用患者日常生活活动能力(ADL)评分作为评估脑功能状态的参考指标,对三者间的关系进行统计学分析。结果不同rLMC分级的组别之间在ADL评分方面差异有统计学意义(P<0.05),ATA评分与ADL评分之间的差异有统计学意义(P<0.05),ATA评分与ADL评分呈正相关关系(P<0.05);rLMC评分和ATA评分间差异无统计学意义(P>0.05)。结论rLMC评分和ATA评分均可作为评估脑功能受损的重要影像学指标,良好的侧支循环能为患者的脑功能状态带来积极的影响,其中二级软脑膜侧支状态的变化可用以预测或评估患者的脑功能状态,以期在临床上为患者制定个性化的治疗方案。Objective To explore the relationship between regional leptomeningeal collateral(rLMC)scoring assessed via threedimensional time of flight magnetic resonance angiography(3D TOF MRA),arterial transit artifact(ATA)scoring obtained from three-dimensional arterial spin labeling(3D-ASL)imaging sequences,and cognitive impairment.Methods A retrospective analysis was conducted on 48 patients who underwent brain imaging,including T1WI,T2WI,T2 FLAIR,3D TOF MRA and 3D-ASL at Xiangya Hospital,Central South University,from January 2018 to October 2023.The rLMC and ATA scores were used to evaluate the status of leptomeningeal collaterals,while the patients'activities of daily living(ADL)scores served as reference indicators for assessing cognitive function.Statistical analyses were performed to evaluate the relationships among the three scores.Results There was a statistically significant difference in ADL scores among different rLMC grading groups(P<0.05).There was a significant difference between the ATA and ADL scores(P<0.05).Spearman's correlation coefficient analysis demonstrated a significant positive correlation between ATA and ADL scores(P<0.05).However,no significant difference was found between rLMC and ATA scores based on variance analysis(P>0.05).Conclusion Both rLMC and ATA scores can serve as important imaging indicators for assessing brain function impairment.A well-developed collateral circulation can have a positive impact on the patient's brain function.In particular,changes in secondary meningeal collateral circulation can be used to predict or evaluate the patient's brain function,with the aim of developing personalized treatment plans in clinical practice.

关 键 词：软脑膜侧支循环 脑功能 磁共振血管成像 三维动脉自旋标记 动脉到达伪影评分 

分 类 号：R445.2[医药卫生—影像医学与核医学] R743[医药卫生—诊断学]