纳米抗体在影像诊断中的应用  

Applications of nanobodies in medical imaging diagnostics

作　　者：孙瑶[1] 谢国柱[1] SUN Yao;XIE Guozhu(Department of Radiation Therapy,Nanfang Hospital,Southern Medical University,Guangzhou 510515,China)

机构地区：[1]南方医科大学南方医院放疗科,广东广州510515

出　　处：《分子影像学杂志》2025年第2期235-241,共7页Journal of Molecular Imaging

基　　金：国家自然科学基金(82373302);广东省科技创新战略专项(2024A0505040015);广州市科技计划“领航”项目(2024A04J6613)。

摘　　要：随着分子生物学、影像技术和信息处理能力的快速发展,医学影像诊断已成为疾病管理中不可或缺的重要手段。影像技术不仅用于疾病的早期筛查和定位,还能通过分子成像提供疾病的分子特征,为精准医学和个性化治疗提供支持。尽管传统影像技术取得显著进展,但其依赖的对比剂和标记探针仍存在局限性。纳米抗体源于骆驼科动物的重链抗体,因其小分子量、高稳定性、高特异性等特点,在医学影像中展现了独特的优势。本文综述了纳米抗体的特性及其在影像诊断中的最新研究进展,重点探讨其在肿瘤成像、感染监测和炎症性疾病诊断中的应用。本文还讨论了纳米抗体在临床转化过程中面临的挑战及当前解决方案。未来,结合技术优化和多模态成像,纳米抗体有望成为精准医疗的重要工具,推动个性化医疗的进一步发展。With the rapid development of molecular biology,imaging technology and information processing ability,medical imaging has become an indispensable tool in disease management.Imaging technology is not only used for early screening and positioning of diseases,but also provides molecular characteristics of diseases through molecular imaging,providing support for precision medicine and personalized treatment.Despite the significant progress in traditional imaging technologies,the contrast agents and labeled probes they depend on still exhibit inherent limitations.Nanobodies,derived from the heavy-chain antibodies of camelids,present unique advantages in medical imaging due to their small molecular size,high stability,and exceptional specificity.This review summarized the distinctive features of nanobodies and the latest research developments on their application in diagnostic imaging,focusing particularly on their use in tumor imaging,infection monitoring,and the diagnosis of inflammatory diseases.The review also discussed the challenges that nanobodies face in clinical translation,and current solution.In the future,combined with technology optimization and multimodal imaging,nano antibodies are expected to become an important tool for precision medicine and promote the further development of personalized medicine.

关 键 词：纳米抗体 医学影像 肿瘤成像 

分 类 号：R445[医药卫生—影像医学与核医学]