成纤维细胞活化蛋白抑制剂PET显像在心肌纤维化中的应用进展  

Research progress of fibroblast activation protein inhibitor PET imaging in the application of myocardial fibrosis

作　　者：韩颜遥 蔡亮 HAN Yanyao;CAI Liang(The Second Affiliated Hospital of Chongqing Medical University,Chongqing 400010,China)

机构地区：[1]重庆医科大学附属第二医院,重庆400010

出　　处：《分子影像学杂志》2025年第2期247-252,共6页Journal of Molecular Imaging

摘　　要：心肌纤维化是一种心脏间质的重塑过程,是心脏受到损伤后出现的一种普遍的愈合反应。成纤维细胞活化蛋白抑制剂(FAPI)是一种靶向成纤维细胞活化蛋白并具有高靶标与背景比的新型药剂。研究表明,FAPI在心肌纤维化的诊断中发挥着关键作用,已成为近期研究的热点。本文主要对FAPI PET显像的应用、心肌纤维化的形式及FAPI PET在各类心脏疾病心肌纤维化中的研究现状展开综述,以揭示FAPI PET在无创监测、早期干预及改善心肌纤维化预后方面的价值,有助于其进一步在临床上推广应用。Myocardial fibrosis is a process of cardiac interstitial remodeling,which is a common healing response after cardiac injury.Fibroblast activation protein inhibitor(FAPI)is a novel agent that targets FAP with a high target-to-background ratio.Current research indicates that FAPI plays a key role in the diagnosis of myocardial fibrosis and has become a recent research focus.This article mainly reviews the application of FAPI PET imaging,the forms of myocardial fibrosis,and the current research status of FAPI PET in myocardial fibrosis in various heart diseases,in order to reveal the value of FAPI PET in noninvasive monitoring,early intervention,and improving the prognosis of myocardial fibrosis,which will help its further clinical promotion and application.

关 键 词：成纤维细胞活化蛋白抑制剂 成纤维细胞活化蛋白 正电子发射断层扫描 心肌纤维化 综述 

分 类 号：R817.4[医药卫生—影像医学与核医学] R542.23[医药卫生—放射医学]