双精氨酸转运系统:细菌致病性的重要门控系统  

Twin-arginine Translocation System:An Important Gating System for Bacterial Pathogenicity

作　　者：林雨菲 赵含羽 赵方荣 郭玉茹 张泽辉 刘明春[1] LIN Yufei;ZHAO Hanyu;ZHAO Fangrong;GUO Yuru;ZHANG Zehui;LIU Mingchun(College of Animal Science and Veterinary Medicine,Shenyang Agricultural University,Shenyang,Liaoning 110866;Liaoning University of Traditional Chinese Medicine,Shenyang,Liaoning 110847)

机构地区：[1]沈阳农业大学动物科学与医学学院,辽宁沈阳110866 [2]辽宁中医药大学,辽宁沈阳110847

出　　处：《中国家禽》2025年第3期121-128,共8页China Poultry

基　　金：辽宁省应用基础研究计划(2022JH2/101300171)。

摘　　要：双精氨酸转运(Twin-arginine translocation,Tat)系统存在于多种细菌中,该系统在质子动力的驱动下转运折叠蛋白,转运的Tat底物蛋白均含有Tat信号肽,其N区包含双精氨酸基序S-R-R-x-F-L-K。细菌Tat系统底物蛋白有磷脂酶C、酰胺酶、细胞分裂蛋白以及铁摄取相关蛋白等。随着对Tat系统的深入探索,Tat底物蛋白被发现能参与细菌的能量代谢、细胞分裂、生物被膜形成、运动、应激反应和毒力等过程的调控。文章从细菌Tat系统的组成、转运模式、校对机制及其与致病过程的相关性等方面进行详细介绍,以期为新型抗感染药物的研发提供参考。Twin-arginine translocation(Tat)system exists in a variety of bacteria and can transport folded proteins driven by proton motive force.The Tat substrate proteins all contain Tat signal peptide,and its N region contains the arginine motif S-R-RX-F-L-K.The Tat system substrate proteins in bacteria include phospholipase C,amidase,cell division proteins and iron uptake related proteins.With the in-depth exploration of Tat system,it is found that Tat substrate proteins can participate in the regulation of energy metabolism,cell division,biofilm formation,movement,stress response and virulence of bacteria.In this review,the composition,transport mode,proofreading mechanism of Tat system and its correlation with pathogenicity were introduced in detail,aiming to provide reference for the development of new anti-infective drugs.

关 键 词：双精氨酸转运系统 致病性 细菌-宿主互作 抗感染药物 

分 类 号：S855.1[农业科学—临床兽医学]