NLRP3炎症小体在术后肠麻痹中的作用研究进展  

Research progress of NLRP3 inflammasome in postoperative ileus

作　　者：李星 陈其城 曹立幸 蒋志 LI Xing;CHEN Qicheng;CAO Lixing;JIANG Zhi(The Second Clinical College of Guangzhou University of Chinese Medicine,Guangzhou 510120,China;Perioperative Application Research Team of Traditional Chinese Medicine,The Second Affiliated Hospital of Guangzhou University of Chinese Medicine,Guangzhou 510120,China)

机构地区：[1]广州中医药大学第二临床医学院,广东广州510120 [2]广州中医药大学第二附属医院围手术期中医药应用研究团队,广东广州510120

出　　处：《老年医学研究》2025年第1期63-67,共5页Geriatrics Research

基　　金：国家自然科学基金资助项目(82204716,五达颗粒下调circZEB1重平衡细胞因子改善术后肠麻痹的分子机制研究);广东省中医院—香港中文大学合作项目(YN2024HK09,五达颗粒介导circZEB1/CTLA4-ILC3s/Trp重平衡细胞因子改善术后肠麻痹的分子机制研究)。

摘　　要：术后肠麻痹(POI)是外科术后十分常见且可能导致严重后果的医源性胃肠动力障碍症状,若患者术后胃肠动力恢复延迟,将引起内环境紊乱、营养不良和感染等,增加其他严重并发症发生风险。NLRP3炎症小体是先天免疫系统的重要组成部分,介导Caspase-1激活和促炎细胞因子IL-1β/IL-18的分泌,以应对微生物感染和细胞损伤。NLRP3炎症小体可能通过调节炎症反应、构造神经炎性环境、影响肠道微生物平衡、诱导细胞焦亡等多种形式在POI中发挥作用。而且,NLRP3炎症小体有望作为新的治疗靶点,通过作用于NLRP3炎症小体可以改善POI。Postoperative ileus(POI)is a very common and potentially serious iatrogenic gastrointestinal motility disor-der after surgery.If there is a delay in the recovery of gastrointestinal motility after surgery,it can lead to internal environ-ment disorders,malnutrition,and infection,which increase the risk of other severe complications.NLRP3 inflammasome is an important component of the innate immune system,mediating the activation of Caspase-1 and the secretion of pro-in-flammatory cytokines IL-1β/IL-18 in response to microbial infection and cell damage.NLRP3 inflammasome may play a role in POI through various mechanisms,such as regulating inflammatory responses,constructing a neuroinflammatory en-vironment,affecting gut microbiota balance,and inducing pyroptosis.Moreover,NLRP3 inflammasome is expected to serve as a new therapeutic target,which can improve POI by acting on NLRP3 inflammasome.

关 键 词：NLRP3炎症小体 术后肠麻痹 炎症反应 免疫应答 治疗靶点 

分 类 号：R656[医药卫生—外科学]