The impact of antioxidant supplements on oocytes and preimplantation embryos of humans and mammals,and their potential application for mitigating the consequences of oxidative stress in vitro:a review  

作　　者：Olga Guseva Natalia Kan Viktoria Chekmareva Daniil Kokorev Pavel Ilyasov 

机构地区：[1]Laboratory of Experimental Embryology and Genomic Modeling of Professional Center for Education and Research in Genetic and Laboratory Technologies,Samara State Medical University,Samara 443099,Russia [2]Laboratory of BigData Analysis,Microorganism Collection,Biobank of Professional Center for Education and Research in Genetic and Laboratory Technologies,Samara State Medical University,Samara 443099,Russia [3]Samara State Medical University,Samara 443099,Russia [4]Laboratory of Genetic Technologies in Microbiology of Professional Center for Education and Research in Genetic and Laboratory Technologies,Samara State Medical University,Samara 443099,Russia [5]Laboratory of Development and Expertise of New Medical Devices for In Vitro Diagnostics of Professional Center for Education and Research in Genetic and Laboratory Technologies,Samara State Medical University,Samara 443099,Russia.

出　　处：《Reproductive and Developmental Medicine》2024年第4期252-263,共12页生殖与发育医学(英文版)

基　　金：The study was carried out within the"Priority-2030"program project(Priority-2030 Grant,Samara State Medical University,Ministry of Health of Russia).

摘　　要：Nowadays,assisted reproductive technologies are becoming increasingly in demand in people’s lives and activities.One of the most important stages of assisted reproductive technology is the cultivation of oocytes and embryosin vitro.The oxidative stress that arises during such cultivation is a great challenge associated with assisted reproductive technology-related activities.It manifests as an excessive amount of reactive oxygen species,resulting in damage to biomolecules,membranes,and other cell components,which significantly reduces the quality and quantity of oocytes and embryos.One possible solution may be the use of antioxidant supplements of various origins.In this review,we summarize and systematize data related to oxidative stress and the use of antioxidants during the cultivation of human,murine,and farm animal-derived oocytes and embryos.In conclusion,we highlight the need for further research to develop a personalized approach in the field of medical and veterinary-assisted reproductive technologies.One result of this approach may be an increase in the probability of obtaining a healthy fetus with the minimum number ofin vitro fertilization attempts.

关 键 词：ANTIOXIDANTS Assisted reproductive technologies ART In vitro fertilization IVF Reactive oxygen species In vitro cultivation 

分 类 号：R714.8[医药卫生—妇产科学]