Recent advances in near-infrared photobiomodulation for the intervention of acquired brain injury  

作　　者：Yujing Huang Yujing Zhang Chen Yang Mengze Xu Zhen Yuan 

机构地区：[1]Ministry of Education,Frontiers Science Center for Precision Oncology Faculty of Health Sciences,University of Macao Macao SAR 999078,P.R.China [2]Center for Cognitive and Brain Sciences Institute of Collaborative Innovation,University of Macao Macao SAR 999078,P.R.China [3]Center for Cognition and Neuroergonomics State Key Laboratory of Cognitive Neuroscience and Learning Beijing Normal University,Zhuhai 519087,P.R.China

出　　处：《Journal of Innovative Optical Health Sciences》2025年第1期1-27,共27页创新光学健康科学杂志(英文)

基　　金：supported by the University of Macao(MYRG2022-00054-FHS and MYRGGRG2023-00038-FHS-UMDF);the Macao Science and Technology Development Fund(FDCT0048/2021/AGJ and FDCT0020/2019/AMJ);Natural Science Foundation of Guangdong Province(EF017/FHS-YZ/2021/GDSTC).

摘　　要：Acquired brain injury(ABI)is an injury that affects the brain structure and function.Traditional ABI treatment strategies,including medications and rehabilitation therapy,exhibit their ability to improve its impairments in cognition,emotion,and physical activity.Recently,near-infrared(NIR)photobiomodulation(PBM)has emerged as a promising physical intervention method for ABI,demonstrating that low-level light therapy can modulate cellular metabolic processes,reduce the in flammation and reactive oxygen species of ABI microenvironments,and promote neural repair and regeneration.Preclinical studies using ABI models have been carried out,revealing the potential of PBM in promoting brain injury recovery although its clinical application is still in its early stages.In this review,we first inspected the possible physical and biological mechanisms of NIR-PBM,and then reported the pathophysiology and physiology of ABI underlying NIR-PBM intervention.Therefore,the potential of NIR-PBM as a therapeutic intervention in ABI was demonstrated and it is also expected that further work can facilitate its clinical applications.

关 键 词：Near-infrared photobiomodulation acquired brain injury traumatic brain injury ischemic stroke 

分 类 号：R651.1[医药卫生—外科学]