蟾酥抗肿瘤作用及机制研究进展  

Research progress on the anti-tumor effect and mechanism of Bufonis Venenum

作　　者：张璐瑶 叶奕含 徐旖旎 赵承光 杨乐和[1] ZHANG Luyao;YE Yihan;XU Yini;ZHAO Chengguang;YANG Lehe(Department of Pulmonary and Critical Care Medicine,The First Affiliated Hospital of Wenzhou Medical University,Wenzhou 325035,China;School of Pharmacy,Wenzhou Medical University,Wenzhou 325035,China)

机构地区：[1]温州医科大学附属第一医院呼吸与危重症科,浙江温州325035 [2]温州医科大学药学院,浙江温州325035

出　　处：《药学研究》2025年第2期179-186,共8页Journal of Pharmaceutical Research

基　　金：教育部产学合作协同育人项目(No.220604408242859)。

摘　　要：蟾酥为蟾蜍科动物中华大蟾蜍或黑眶蟾蜍的干燥分泌物,其主要成分包括蟾蜍内酯类、蟾蜍色胺类、甾醇类等。研究已证实,蟾酥主要通过抑制肿瘤细胞增殖、诱导肿瘤细胞凋亡、阻滞肿瘤细胞周期、抑制肿瘤细胞侵袭与转移、抑制肿瘤血管形成、增强免疫、调节免疫微环境、逆转耐药性等机制发挥抗肿瘤作用。本文就蟾酥的化学成分及结构、制剂发展、抗肿瘤作用及机制、临床试验进行综述,以期为蟾酥的药物研发及临床应用提供参考。Bufonis Venenum is the dry secretion of the Bufo bufo gargarizans Cantor or Bufo melanostictus Schneider,which belongs to the toad family.Its main components include bufadienolides,bufotenines,sterols and so on.Recent studies have shown that Bufonis Venenum has a good anti-tumor effect,mainly through inhibiting tumor cell proliferation,inducing tumor cell apoptosis,blocking tumor cell cycle,inhibiting tumor cell invasion and metastasis,inhibiting tumor angiogenesis,enhancing immunity,regulating immune microenvironment,reversing drug resistance and other mechanisms.This review summarizes the chemical composition,structure and preparation of Bufonis Venenum,the anti-tumor effect and mechanism of its main active ingredients,as well as clinical trial,to provide reference for the drug development and clinical application of Bufonis Venenum.

关 键 词：蟾酥 抗肿瘤 机制 研究进展 

分 类 号：R285[医药卫生—中药学]