非载药聚乳酸-羟基乙酸共聚物降解特性研究  

Study on the Degradation Characteristics of Non-Drug-Loaded Poly(lactic-co-glycolic acid)

作　　者：初洪珍 张亚楠 戚盼 赵云丽[1] CHU Hongzhen;ZHANG Yanan;QI Pan;ZHAO Yunli(School of Pharmacy,Shenyang Pharmaceutical University,Shenyang 117004,China;Changchun Gene Science Pharmaceutical Co.,Ltd.,Changchun 130000,China)

机构地区：[1]沈阳药科大学药学院,辽宁沈阳117004 [2]长春金赛药业有限责任公司,吉林长春130000

出　　处：《工业微生物》2025年第1期74-77,共4页Industrial Microbiology

摘　　要：文章以乳酸-羟基乙酸共聚物(PLGA)制备的非载药微球为模型,研究PLGA微球的缓释机理,以筛选出能反映体内降解行为的体外释放方法。同时,建立凝胶渗透色谱(GPC)方法,用于测定非载药PLGA微球的分子量并验证其效果,通过体外降解研究非载药微球在降解过程中的动态变化,结合差示扫描量热仪(DSC)和扫描电子显微镜(SEM)等辅助表征手段全面考察其降解特性。文章考察了非载药PLGA与体内相近降解周期的体外释放条件,有助于缩短辅料筛选周期,为载药微球的体外释放研究提供科学依据。The paper took the blank PLGA microsphere as a model to explore the slow-release mechanism of PLGA microspheres,so as to select the in-vitro release method that reflecting the release behavior in-vivo.The gel permeation chromatography(GPC)method was established to determine the molecular weight of the blank PLGA microspheres and verify their effectiveness.The dynamic changes of blank microspheres during the degradation process were studied by in vitro degradation,and the degradation characteristics were investigated by auxiliary characterization means,such as the differential scanning calorimeter(DSC)and the scanning electron microscope(SEM).In this paper,the release conditions of blank PLGA and similar degradation cycles in-vivo were investigated,which can shorten the screening cycle of excipients,and provide the scientific basis for the study of in-vitro release of drug-loaded microspheres.

关 键 词：生物可降解材料 缓释微球 聚乳酸-羟基乙酸共聚物 

分 类 号：TQ460.4[化学工程—制药化工] TQ317