脂肪来源干细胞及外泌体调控慢性创面炎症和血管重建机制的研究进展  

Research Progress on the Mechanism of Adipose-derived Stem Cells and Exosomes in the Modulation of Chronic Wounds Inflammation and Angiogenesis

作　　者：付强[1] 郑璨(综述) 陈敏亮(审校)[1] FU Qiang;ZHENG Can;CHEN Minliang(Department of Burn and Plastic Surgery,Plastic and Reconstructive Surgery Unit,Fourth Medical Center,PLA General Hospital,Beijing 100048,China)

机构地区：[1]解放军总医院第四医学中心烧伤整形医学部整形修复科,北京100048

出　　处：《中国美容医学》2025年第3期171-175,共5页Chinese Journal of Aesthetic Medicine

基　　金：解放军总医院青年自主创新科学基金项目(编号:22QNFC048)。

摘　　要：本文通过查阅近年来有关ADSCs及外泌体治疗慢性难愈性创面的文献,分析总结其修复机制及研究最新进展。ADSCs作为组织工程和再生医学理想的种子细胞,具有自我更新和多向分化的潜能,能够显著地调控机体炎症反应与血管生成。ADSCs-Exos具有类似ADSCs的功能,能够加速细胞增殖、分化,促进细胞迁移,调控血管生成速度,是近年来针对慢性创面进行无细胞疗法的研究热点。近年来通过不断开发新的优化方法,使ADSCs及外泌体对创面的修复效果得到进一步增强。但两者在临床应用中仍存在一定局限性,相关研究新进展综述如下。The related literatures about chronic wounds treated by ADSCs and ADSCs-Exos in recent years were reviewed,and the repair mechanism was analyzed and summarized.As ideal seed cells for wound healing and tissue regeneration,ADSCs have the potential of self-renewal and multidirectional differentiation.It can significantly regulate inflammatory response and angiogenesis.ADSCs-Exos have similar functions to ADSCs,which can accelerate cell proliferation and differentiation,promote cell migration,and regulate the rate of angiogenesis.It has become a research hotspot of cell-free therapy for chronic wounds in recent years.In recent years,through the continuous development of new optimization methods,the repair effect of ADSCs and exosomes on wound healing has been further enhanced.But there are still some limitations in their application.This article reviews the modulation of chronic wounds inflammation and angiogenesis with ADSCs and ADSCS-Exos.

关 键 词：脂肪来源干细胞 外泌体 慢性创面 创面修复 炎症 血管重建 

分 类 号：R641[医药卫生—外科学]