SAS macro programme for Bang's Blinding Index to assess and visualise the success of blinding in randomised controlled trials  

作　　者：Zongshi Qin Yongpei Yu Hongqiu Gu Dongdong Shi Zhen Wang Jiani Wu Toshiaki Furukawa Yangfeng Wu 

机构地区：[1]Peking University Clinical Research Institute,Beijing,China [2]Department of Neurology and China National Clinical Research Center for Neurological Diseases,Bejing Tiantan Hospital,Capital Medical University,Bejing,China [3]Shanghai Mental Health Center,Shanghai Jiao Tong University School of Medicine,Shanghai,China [4]Department of Acupuncture and Neurology,Guang'anmen Hospital,China Academy of Chinese Medical Sciences,Beijing,China [5]Department of Health Promotion and Human Behavior,Kyoto University Graduate School of Medicine and School of Public Health,Kyoto,Japan

出　　处：《General Psychiatry》2024年第6期598-605,共8页综合精神医学(英文)

基　　金：funded by International Postdoctoral Exchange Fellowship Program(YJ20220238);China Postdoctoral Science Foundation(2023TQ0018)。

摘　　要：This paper aims to present a Statistical Analysis Software(SAS)macro%BBlplus,offering estimation and visualisation methods for the Bang's Blinding Index(BBl)for randomised controlled trials(RCTs)with various designs.We developed the SAS macro programme%BBlplus to facilitate the implementation of BBl.This userfriendly programme allows for easy and rapid estimation and visualisation of BBl across different scenarios,including pairwise comparison RCTs with two arms,double-dummy design RCTs with three arms and factorial design RCTs with four arms.The programme requires no pre-existing data set,and users only need to input the number of individuals of correct,uncertain or wrong guesses in each intervention or control group.We illustrate the functionality of%BBlplus using blinding assessment data from three previously published RCTs:BBR(adjunctive berberine reduces antipsychotic-associated weight gain and metabolic syndrome in patients with schizophrenia:a randomised controlled trial),SELECTTDcS(the sertraline versus electrical current therapy for treating depression clinical study:results from a factorial,randomised controlled trial)and ELECT-TDCS(trial of electrical direct-current therapy versus escitalopram for depression)studies.The programme estimates the BBI for each arm,providing point estimates,95%Cl and associated p values.Additionally,%BBlplus can visualise the estimations through forest plots and make the judgement for the success of blinding easily and rapidly.This tool caters to the needs of clinical trial investigators,offering a comprehensive solution for estimating and visualising the blinding index under various RCT designs.

关 键 词：offering SAS ESTIMATION 

分 类 号：C92[社会学—人口学]