特布他林联合布地奈德治疗小儿喘息性肺炎的疗效及不良反应分析  

Analysis of the Therapeutic Effect and Adverse Reactions of Terbutaline Combined with Budesonide in the Treatment of Pediatric Wheezing Pneumonia

作　　者：温中扬 林利娟 WEN Zhongyang;LIN Lijuan(Kuiyong People's Hospital of Dapeng New District,Shenzhen 518119,Guangdong Province,China)

机构地区：[1]大鹏新区葵涌人民医院,广东深圳518119

出　　处：《中国实用乡村医生杂志》2024年第12期72-74,78,共4页Chinese Practical Journal of Rural Doctor

摘　　要：目的 探讨特布他林联合布地奈德对小儿喘息性肺炎临床恢复、肺功能及炎症指标的影响。方法 选择2022年12月—2023年12月深圳市大鹏新区葵涌人民医院收治的喘息性肺炎患儿96例,随机分为对照组和观察组各48例。两组患儿均以肺力咳合剂作为基础用药,对照组在基础治疗基础上吸入布地奈德;而观察组则进一步联合特布他林。比较两组患儿的临床指标、肺功能、炎症反应指标及不良反应。结果 治疗后,观察组临床各症状、体征消失时间及住院时间均低于对照组,差异有统计学意义(P<0.05);观察组1秒用力呼气容积、呼气峰流速、用力肺活量水平高于对照组,差异有统计学意义(P<0.05);观察组肿瘤坏死因子-α、白细胞介素-6、降钙素原水平低于对照组,差异有统计学意义(P<0.05);两组不良反应发生率差异无统计学意义(P>0.05)。结论 特布他林联合布地奈德能有效促进喘息性肺炎患儿临床恢复,有效提高其肺功能,降低机体炎症反应,且安全性较高。Objective To explore the effects of terbutaline combined with budesonide on clinical recovery,lung function,and inflammatory markers in children with wheezing pneumonia.Methods Ninety-six children with wheezing pneumonia admitted to Kuiyong People's Hospital in Dapeng New District of Shenzhen from December 2022 to December 2023 were randomly divided into a control group and an observation group,with 48 cases in each group.Both groups of children were treated with pulmonary cough mixture as the basic medication,while the control group inhaled budesonide on the basis of basic treatment,and the observation group further combined with terbutaline.The clinical indicators,lung function,inflammatory response indicators,and adverse reactions between two groups of children were compared.Results After treatment,the disappearance time of clinical symptoms,signs,and hospitalization time in the observation group were lower than those in the control group(P<0.05).The levels of forced expiratory volume in the first second,peak expiratory flow,and forced vital capacity in the observation group were higher than those in the control group(P<0.05).The levels of tumor necrosis factor-α,interleukin-6,and procalcitonin in the observation group were lower than those in the control group(P<0.05).There was no statistically significant difference in the incidence of adverse reactions between the two groups(P>0.05).Conclusion The combination of terbutaline and budesonide can effectively promote the clinical recovery of children with wheezing pneumonia,improve their lung function,reduce the body's inflammatory response,and has high safety.

关 键 词：特布他林 布地奈德 小儿 喘息性肺炎 临床疗效 不良反应 

分 类 号：R725.6[医药卫生—儿科]