骨骼干细胞在军事再生医学中的应用价值研究进展  

Research progress in applicability of skeletal stem cells in military regenerative medicine

作　　者：虞富豪 丁丽 朱恒 YU Fuhao;DING Li;ZHU Heng(Academy of Military Medical Sciences,Academy of Military Sciences,Beijing 100850,China;Graduate School,Air Force Military Medical University,Xi'an 710032,China;Department of Hematology,Air Force Medical Center,Beijing 100142,China)

机构地区：[1]军事科学院军事医学研究院,北京100850 [2]空军军医大学研究生院,西安710032 [3]空军军医大学空军特色医学中心血液科,北京100142

出　　处：《军事医学》2024年第12期940-945,共6页Military Medical Sciences

基　　金：国家干细胞重点研发专项(2022YFA1103500,2022YFA1104100);国家自然科学基金项目(82372373,82172388);北京市自然科学基金项目(7242141,7192203,7182123,L212065)。

摘　　要：军事训练和军事作业常导致多种形式的骨骼损伤,包括疲劳性骨折、急性骨折、骨软骨缺损、放射性骨损伤等。骨骼干细胞是近年来发现的人和高等动物骨骼组织内源性干细胞,具备分化为骨、软骨和骨髓基质的能力,是骨发育、骨稳态维持和骨再生修复的重要种子细胞之一。骨骼干细胞具有高度群体异质性和时空分布特异性,不同部位骨骼干细胞的细胞表型和修复能力不尽相同。因此,骨骼干细胞在不同军事损伤中的响应规律及机制有所差别。该文从骨骼干细胞来源、骨修复作用机制及其在军事再生医学中的潜在应用价值等方面进行综述。Military training and operations usually lead to such skeletal injuries as fatigue fractures,acute bone fractures,osteochondral defects,and radiation-induced bone injury.Skeletal stem cells(SSCs)are newly-identified innate tissue specific stem cells in skeletons which are capable of differentiating into bone,cartilage and bone marrow stromal tissues,and are one of the seed cells critical to the development,homeostasis,and regeneration of skeletons.SSCs are highly heterogenous in cellular subpopulations and spatiotemporal distributions,which is why their cellular immunopheto type and regenerative capacity are different in different anatomical sites.Thus,there is considerable difference in the response of SSCs to military injuries and in the underlying mechanisms.This review discussed the sources of SSCs,underlying mechanisms of SSCs-mediated skeletal regeneration,and the potential applications of SSCs in military regenerative medicine.

关 键 词：骨骼干细胞 军事再生医学 骨折 骨软骨缺损 放射性骨损伤 

分 类 号：R823[医药卫生—临床医学]