Early intermittent cholesterol exposure accelerates atherosclerosis:an oscillating amplifier calling for preemptive control  

作　　者：Maria Kral Yvonne Döring Christian Weber 

机构地区：[1]Institute for Cardiovascular Prevention(IPEK),Ludwig-Maximilians-Universität München(LMU Munich),Pettenkoferstr 9,80336 Munich,Germany [2]DZHK(German Center for Cardiovascular Research),Partner Site Munich Heart Alliance,Munich,Germany [3]Department of Angiology,Swiss Cardiovascular Center,Inselspital,Bern University Hospital,University of Bern,Bern,Switzerland [4]Department of Biochemistry,Cardiovascular Research Institute Maastricht(CARIM),Maastricht University Medical Centre,Maastricht,The Netherlands

出　　处：《Signal Transduction and Targeted Therapy》2024年第12期5343-5345,共3页信号转导与靶向治疗(英文)

基　　金：support was received for the research,authorship,and/or publication of this article;supported in part by funding to YD and CW through the Deutsche Forschungsgemeinschaft(SFB1123-A1).

摘　　要：A recent publication in Nature1 identified early intermittent hyperlipidemia as a new determinant of atherosclerosis driving an altered phenotype of arterial-resident macrophages with defects in autophagy-and efferocytosis-related pathways.These intriguing findings infer the need for preemptive control of cholesterol already at younger age to prevent and limit atherosclerosis.

关 键 词：AMPLIFIER YOUNGER driving 

分 类 号：TN7[电子电信—电路与系统]