芦荟苷治疗慢传输型便秘最适剂量的探索  

Exploration of the Optimal Dose of Aloin for Treatment of Slow Transmit Constipation

作　　者：廖伊琦 黄炜锐 岩迎雪 余祥彬[1,2] 余越 LIAO Yi-qi;HUANG Wei-rui;YAN Ying-xue;YU Xiang-bin;YU Yue(School of Pharmacy,Fujian Medical University,Fuzhou 350122,China;Fujian Center for Safety Evaluation of New Drug,Fuzhou 350122,China)

机构地区：[1]福建医科大学药学院,福建福州350122 [2]福建省新药安全性评价中心,福建福州350122

出　　处：《海峡药学》2025年第1期4-9,共6页Strait Pharmaceutical Journal

基　　金：福建医科大学高层次人才科研启动经费(No.60000166);福建省科技厅高校产学合作项目(No.2021Y4011);药物分析与检验医学福建省高校重点实验室(莆田学院)开放基金(No.PALM 202208)。

摘　　要：目的本项研究旨在确定芦荟苷治疗慢传输型便秘的最适剂量。方法通过洛哌丁胺诱导大鼠构建慢传输型便秘模型,随后将这些模型大鼠随机分为六个组:空白对照组、模型组、阳性对照组、以及接受低(5 mg·kg^(-1))、中(10 mg·kg^(-1))、高(20 mg·kg^(-1))三个剂量的芦荟苷治疗组。各组大鼠均接受为期三周的治疗。在治疗期间,持续监测并记录大鼠的体重变化、粪便特性、水分含量,以及肠道蠕动速度,并对大鼠结肠进行了H&E染色和AB-PAS染色以观察其组织形态学变化,并对比各组大鼠的脏器系数。结果与模型组相比,接受中剂量芦荟苷治疗的大鼠在多项指标上均表现出显著的改善,包括粪便品质、水分含量的增加以及肠道推进率的提升。结论本研究表明,在10 mg·kg^(-1)的剂量下,芦荟苷对慢传输型便秘具有显著的治疗效果。因此,推荐这一剂量作为治疗慢传输型便秘的有效剂量。OBJECTIVE To investigate the optimal dose of aloin for the treatment of slow transit constipation.METHODS A slow transit constipation model was established by the loperamide modeling method in rats,then randomly divided into six groups:blank control group,model group,positive control group,and three aloin treatment groups receiving low(5 mg·kg^(-1)),medium(10 mg·kg^(-1)),and high(20 mg·kg^(-1))doses.All groups received treatment for three weeks.During the treatment period,the body weight,fecal status and fecal moisture content,intestinal transit rate.The colons of the rats were subjected to H&E staining and AB-PAS staining to observe histo-morphological changes,and organ coefficients of rats in each group were recorded.RESULTS Compared to the model group,rats treated with a medium dose of aloin showed significant improvements in various indicators,including stool quality,increased moisture content,and enhanced intestinal transit rate.CONCLUSION This study demonstrated that aloin at a dose of 10 mg·kg^(-1)has a significant therapeutic effect on slow transit constipation.Therefore,this dose is recommended as an effective dose for the treatment of slow transit constipation.

关 键 词：芦荟苷 慢传输型便秘 洛哌丁胺 粪便含水率 肠道推进率 剂量效应 

分 类 号：R965[医药卫生—药理学]