耳穴埋豆联合疏肝健脾方治疗2型糖尿病伴抑郁的临床研究  

Clinical Study on Auricular Buried Beans Combined with Shugan Jianpi Decoction in the Treatment of Type 2 Diabetes Mellitus with Depression

作　　者：杨天成 崔志梅[2] 张淑敏 王优 白建乐[2] YANG Tian-cheng;CUI Zhi-mei;ZHANG Shu-min;WANG You;BAI Jian-le(Graduate School of Hebei University of Traditional Chinese Medicine,Shijiazhuang,Hebei,050091,China;Second Department of Endocrinology,Shijiazhuang Hospital of Traditional Chinese Medicine,Shijiazhuang,Hebei,050011,China;Department of Internal Medicine,Dingzhou People's Hospital,Dingzhou,Hebei,073000,China;Department of Health Examination,Dingzhou People's Hospital,Dingzhou,Hebei,073000,China)

机构地区：[1]河北中医药大学研究生学院,河北石家庄050091 [2]石家庄市中医院内分泌二科,河北石家庄050011 [3]定州市人民医院内科,河北定州073000 [4]定州市人民医院健康体检科,河北定州073000

出　　处：《现代生物医学进展》2025年第1期53-58,共6页Progress in Modern Biomedicine

基　　金：河北省中医药管理局科研计划项目(2020339)。

摘　　要：目的:观察耳穴埋豆联合疏肝健脾方治疗2型糖尿病(T2DM)伴抑郁的临床疗效。方法:采用随机数字表法,将石家庄市中医院2022年4月~2023年11月期间收治的136例T2DM伴抑郁患者分为对照组(68例,耳穴埋豆治疗)和研究组(68例,对照组的基础上接受疏肝健脾方治疗)。对比两组中医证候积分、汉密尔顿抑郁量表(HAMD)-17评分、血糖指标、血脂指标、血清神经内分泌指标。结果:治疗后,研究组5-羟色氨酸(5-HT)、多巴胺(DA)、高密度脂蛋白胆固醇(HDL-C)较对照组更高,糖化血红蛋白(HbAlc)、总胆固醇(TC)、HAMD-17评分、餐后2 h血糖(2hPG)、中医证候积分、甘油三酯(TG)、空腹血糖(FPG)、促肾上腺皮质激素(ACTH)、低密度脂蛋白胆固醇(LDL-C)较对照组更低(P<0.05)。结论:耳穴埋豆联合疏肝健脾方治疗T2DM伴抑郁患者,可改善临床症状,可能与调节糖脂代谢、血清神经内分泌有关。Objective:To observe the clinical efficacy of auricular buried beans combined with shugan jianpi decoction in the treatment of type 2 diabetes mellitus(T2DM)with depression.Methods:136 patients with T2DM and depression admitted to Shijiazhuang Hospital of Traditional Chinese Medicine from April 2022 to November 2023 were divided into control group(68 cases,treated with auricular buried beans)and study group(68 cases,treated with shugan jianpi decoction on the basis of control group)by random number table method.The traditional chinese medicine syndrome score,hamilton de-pression scale(HAMD)-17 score,blood glucose indexes,blood lipid indexes and serum neuroendocrine indexes were compared between two groups.Results:After treatment,5-hydroxytryptophan(5-HT),dopamine(DA)and high-density lipoprotein cholesterol(HDL-C)in study group were higher than those in control group,and glycosylated hemoglobin(HbAlc),total cholesterol(TC),HAMD-17 score,2 h postprandial blood glucose(2hPG),traditional chinese medicine syndrome score,triglyceride(TG),fasting blood glucose(FPG),adrenocorticotropic hormone(ACTH),low density lipoprotein cholesterol(LDL-C)were lower than those in control group(P<0.05).Conclusion:Auricular buried beans combined with shugan jianpi decoction in the treatment of T2DM patients with depression,which can improve clinical symptoms,may be related to the regulation of glucose and lipid metabolism and serum neuroendocrine.

关 键 词：耳穴埋豆 疏肝健脾方 2型糖尿病伴抑郁 血糖 血脂 神经内分泌 

分 类 号：R24[医药卫生—中医临床基础] R58[医药卫生—中医学]