消肿止痛汤联合湿润烧伤膏对湿热下注型低位肛周脓肿术后创面愈合的影响  

Effect of Combined Treatment with Moist Exposed Burn Ointment and Xiaozhong Zhitong Decoction on Postoperative Wound Healing of Damp-Heat-Infiltrating Type Low-Lying Perianal Abscesses

作　　者：张乐 钟伶莉 李振宇[2] 谢海洋[1] 罗婷 孙锐 ZHANG Le;ZHONG Ling-li;LI Zhen-yu;XIE Hai-yang;LUO Ting;SUN Rui(Department of Integrated Traditional Chinese and Western Medicine Anorectal,Affiliated Hospital of North Sichuan Medical College,Nanchong,Sichuan,637000,China;Department of Anorectal,Jintang First People's Hospital,Jintang,Sichuan,610400,China)

机构地区：[1]川北医学院附属医院中西医结合肛肠科,四川南充637000 [2]金堂县第一人民医院肛肠科,四川金堂610400

出　　处：《现代生物医学进展》2025年第1期59-64,共6页Progress in Modern Biomedicine

基　　金：四川省中医药管理局科学技术研究专项课题(2020LC0099)。

摘　　要：目的:观察湿热下注型低位肛周脓肿患者术后采用消肿止痛汤联合湿润烧伤膏治疗的创面愈合情况。方法:按照双色球法将川北医学院附属医院2021年12月~2023年12月期间收治的146例湿热下注型低位肛周脓肿患者(均实施肛周脓肿切开引流术)分为对照组(73例,术后采用湿润烧伤膏治疗)和观察组(73例,术后采用消肿止痛汤熏洗坐浴联合湿润烧伤膏治疗)。对比两组中医证候积分、创面愈合情况、创面疼痛评分、创面分泌物评分、创面肉芽生长评分以及血清生长因子[血清酸性成纤维细胞生长因子(aFGF)、碱性成纤维细胞生长因子(bFGF)]。结果:与对照组治疗后相比,观察组肛周疼痛、流脓血或肛周硬块且未见流脓、局部红肿热痛、总分更低,血清aFGF、bFGF水平更高(P<0.05)。观察组术后7 d、14 d的创面愈合率高于对照组,创面愈合时间短于对照组(P<0.05)。与对照组治疗3 d、7 d、14 d、21 d后相比,观察组创面疼痛评分、创面分泌物评分、创面肉芽生长评分更低(P<0.05)。结论:消肿止痛汤熏洗坐浴联合湿润烧伤膏用于湿热下注型低位肛周脓肿术后患者,可减少创面分泌物,减轻患者术后疼痛,加快创面肉芽生长,促进术后创面愈合,提高血清生长因子水平。Objective:To observe the treatment of xiaozhong zhitong decoction combined with moist exposed burn ointment after operation for damp-heat-infiltrating type low-lying perianal abscesses,wound healing of the patient.Methods:146 patients with damp-heat-infiltrating type low-lying perianal abscesses(all treated with perianal abscess incision and drainage)in Affiliated Hospital of North Sichuan Medical College from December 2021 to December 2023 were divided into control group(73 cases,Moist burn ointment was used for treatment after operation)and observation group(73 cases,After operation,the patients were treated with Xiaozhong Zhitong decoction fumigation and sitz bath combined with moist burn ointment)according to the two-color ball method.The traditional chinese medicine syndrome scores,wound healing,wound pain score,wound secretion score,wound granulation growth score and serum growth factors[serum acidic fibroblast growth factor(aFGF),basic fibroblast growth factor(bFGF)]were compared between two groups.Results:Compared with control group after treatment,the perianal pain,purulent blood or perianal hard mass without pus,local swelling and heat pain,total score were lower in observation group,and serum aFGF and bFGF levels were higher(P<0.05).The wound healing rate of 7 d and 14 d after operation in observation group was higher than that in control group,and the wound healing time was shorter than that in control group(P<0.05).Compared with the control group after 3 d,7 d,14 d and 21 d of treatment,the wound pain score,wound secretion score and wound granulation growth score in the observation group were lower(P<0.05).Conclusion:Xiaozhong Zhitong Decoction fumigation sitz bath combined with MEBO can reduce wound secretion,relieve postoperative pain,accelerate wound granulation growth,promote postoperative wound healing and increase serum growth factor level in patients with low perianal abscess of damp-heat pouring downward type.

关 键 词：消肿止痛汤 湿润烧伤膏 湿热下注型 肛周脓肿 创面愈合 生长因子 

分 类 号：R657.1[医药卫生—外科学]