改良弗明汉卒中量表评分联合外周血脂联素、D-二聚体对孤立性眩晕患者并发脑梗死的评估价值  

Evaluation Value of Modified Framingham Stroke Scale Score Combined with Peripheral Blood Adiponectin and D-Dimer in Isolated Vertigo Patients with Cerebral Infarction

作　　者：杨超群 冯静安 谭璆 YANG Chao-qun;FENG Jing-an;TAN Qiu(Department of Neurology,Huanggang People's Hospital,Huanggang,Hubei,438000,China;Department of Neurology,Changyang Tujia Autonomous County People's Hospital,Changyang,Hubei,443500,China)

机构地区：[1]黄冈市人民医院神经内科,湖北黄冈438000 [2]长阳土家族自治县人民医院神经内科,湖北长阳443500

出　　处：《现代生物医学进展》2025年第2期311-317,共7页Progress in Modern Biomedicine

基　　金：黄冈市科技计划项目(hgkj20180283)。

摘　　要：目的:探讨改良弗明汉卒中量表(FSP)评分联合外周血脂联素(APN)、D-二聚体(D-D)评估孤立性眩晕(Ⅳ)患者并发脑梗死的临床价值。方法:选取2022年1月~2024年6月我院收治的Ⅳ患者157例(Ⅳ组)和同期80名健康体检志愿者(对照组),根据是否发生脑梗死将Ⅳ患者分为脑梗死组(50例)和非脑梗死组(107例)。计算FSP评分,采用酶联免疫吸附法检测外周血APN、D-D水平。多因素非条件Logistic回归分析确定Ⅳ患者并发脑梗死的影响因素,绘制受试者工作特征(ROC)曲线分析FSP评分和外周血APN、D-D单独及联合评估Ⅳ患者并发脑梗死的价值。结果:Ⅳ组FSP评分和外周血D-D水平高于对照组,APN水平低于对照组(P<0.05)。157例Ⅳ患者脑梗死并发率为31.85%(50/157)。脑梗死组糖尿病比例、高血压比例、FSP评分和外周血D-D水平高于非脑梗死组,APN水平低于非脑梗死组(P<0.05)。Ⅳ患者并发脑梗死的独立危险因素为高血压、FSP评分高、D-D水平高,独立保护因素为APN水平高(P<0.05)。FSP评分联合外周血APN、D-D评估Ⅳ患者并发脑梗死的曲线下面积为0.927,大于FSP评分、APN、D-D单独评估的0.771、0.780、0.794。结论:Ⅳ患者FSP评分和外周血D-D水平升高,APN水平降低,与并发脑梗死有关,FSP评分联合外周血APN、D-D评估Ⅳ患者并发脑梗死的价值较高。Objective:To investigate the clinical value of modified framingham stroke scale(FSP)score combined with peripheral blood adiponectin(APN)and D-dimer(D-D)in evaluating isolated vertigo(Ⅳ)patients with cerebral infarction.Methods:157 Ⅳ patiensts(Ⅳ group)and 80 health examination volunteers during the same period(control group)who were admitted to our hospital from January 2022 to June 2024 were selected,Ⅳ patients were divided into cerebral infarction groupp(50 cases)and non-cerebral infarction group(107 cases)according to the occurrence of cerebral infarction.The FSP score was calculated,and peripheral blood APN and D-D levels were detected by enzyme-linked immunosorbent assay.The influencing factors of Ⅳ patients with cerebral infarction were determined by multivariate unconditional Logistic regression analysis,the value of FSP score and peripheral blood APN and D-D assessment alone and in combination in evaluating Ⅳ patients with cerebral infarction was analyzed by drawn receiver operating characteristic(ROC)curve.Results:The FSP score and peripheral blood D-D level in Ⅳ group were higher than those in control group,and the APN level was lower than that in control group(P<0.05).The incidence of cerebral infarction in 157 Ⅳ patients was 31.85%(50/157).The proportion of diabetes mellitus,proportion of hypertension,FSP score and peripheral blood D-D level in cerebral infarction group were higher than those in non-cerebral infarction group,and the APN level was lower than that in non-cerebral infarction group(P<0.05).The independent risk factors of Ⅳ patients with cerebral infarction were hypertension,high FSP score and high D-D level,and the independent protective factor was high APN level(P<0.05).The area under the curve of FSP score combined with peripheral blood APN and D-D in evaluating Ⅳ patients with cerebral infarction was 0.927,which was greater than 0.771,0.780 and 0.794 of FSP score,APN and D-D alone.Conclusion:FSP score and peripheral blood D-D level increase in Ⅳ patients,and the A

关 键 词：孤立性眩晕 脑梗死 改良弗明汉卒中量表评分 脂联素 D-二聚体 评估价值 

分 类 号：R3[医药卫生—基础医学] R743