颈动脉超声联合血清血小板活化因子、血栓调节蛋白对TIA患者继发脑梗死的预测价值  

Predictive Value of Carotid Ultrasound Combined with Serum Platelet Activating Factor and Thrombomodulin for Secondary Cerebral Infarction in Patients with TIA

作　　者：张进[1] 唐军 崔洋洋[3] ZHANG Jin;TANG Jun;CUI Yang-yang(Department of Ultrasonography,Funing County People's Hospital of Yancheng,Yancheng,Jiangsu,224400,China;Department of Neurosurgery,Funing County People's Hospital of Yancheng,Yancheng,Jiangsu,224400,China;Department of Laboratory,Funing County People's Hospital of Yancheng,Yancheng,Jiangsu,224400,China)

机构地区：[1]盐城市阜宁县人民医院超声科,江苏盐城224400 [2]盐城市阜宁县人民医院神经外科,江苏盐城224400 [3]盐城市阜宁县人民医院检验科,江苏盐城224400

出　　处：《现代生物医学进展》2025年第2期325-332,共8页Progress in Modern Biomedicine

基　　金：盐城市重点研发计划(社会发展)项目(YCBE202471)。

摘　　要：目的:探讨颈动脉超声联合血清血小板活化因子(PAF)、血栓调节蛋白(TM)对短暂性脑缺血发作(TIA)患者继发脑梗死的预测价值。方法:选取本院2021年3月至2023年12月收治的200例TIA患者进行研究,依据其90 d内继发脑梗死情况分为脑梗死组(n=64)和非脑梗死组(n=136)。对比两组颈动脉超声参数、血清PAF、TM水平;比较两组临床资料和实验室指标;采用多因素Logistic回归方程分析危险因素;采用受试者工作特征(ROC)曲线分析预测价值。结果:与非脑梗死组比较,脑梗死组颈动脉内中膜厚度、颈动脉狭窄程度、血清PAF及TM更高,TIA首次发作至就诊时间、TIA持续时间均更长(P<0.05);颈动脉内中膜厚度、颈动脉狭窄程度、血清PAF、TM水平、TIA首次发作至就诊时间为影响TIA患者继发脑梗死的独立危险因素(P<0.05);颈动脉超声参数、血清PAF、TM联合预测TIA患者继发脑梗死的曲线下面积为0.850,高于单一指标检测。结论:颈动脉超声参数、血清PAF、TM是TIA患者继发脑梗死的影响因素,三者联合检测可以提升对继发脑梗死风险的预测价值,具有一定的临床应用价值。Objective:To investigate the predictive value of carotid ultrasound combined with serum platelet activating factorr(PAF)and thrombomodulin(TM)for secondary cerebral infarction in patients with transient ischemic attack(TIA).Methods:200 patients with TIA who were admitted to our hospital.from March 2021 to December 2023 were selected for study.Patients were divided into cerebral infarction groupp(n=64)and non-cerebral infarction group(n=136)according to their secondary cerebral infarction within 90 days.The carotid ultrasound parameters,serum PAF and TM levels were compared between two groups.The clinical data and laboratory indexes in two groups were compared.The risk factors was analyzed by multivariate logistic regression equation,and the predictive valu was analyzed by receiver operating characteristic(ROC)curve.Results:Compared with non-cerebral infarction group,the carotid intima-media thickness,carotid stenosis,serum PAF and TM were higher in cerebral infarction group,and the time from the first attack of TIA to the visit and the duration of TIA were longer(P<0.05).The carotid intima-media thickness,the degree of carotid stenosis,serum PAF,TM levels,and the time from the first attack of TIA to the visit were independent risk factors for secondary cerebral infarction in TIA patients(P<0.05).The area under the curve of carotid ultrasound parameters,serum PAF and TM combined to predict secondary cerebral infarction in TIA patients was 0.850,which was higher than that of single index detection.Conclusion:Carotid ultrasound parameters,serum PAF and TM are the influencing factors of secondary cerebral infarction in TIA patients,the combined detection of the three can improve the predictive value of secondary cerebral infarction risk,which has certain clinical application value.

关 键 词：颈动脉超声 血小板活化因子 血栓调节蛋白 短暂性脑缺血发作 脑梗死 预测价值 

分 类 号：R3[医药卫生—基础医学] R543.5R817.4