Acupuncture Therapy on Dysphagia in Patients with Parkinson's Disease:A Randomized Controlled Study  

作　　者：ZENG Hong-ji ZHAO Wei-jia LUO Peng-chao ZHANG Xu-yang LUO Si-yu LI Yi LI He-ping WANG Liu-gen ZENG Xi 

机构地区：[1]School of Public Health,Zhengzhou University,Zhengzhou,450000,China [2]Institute of Dysphagia,Zhengzhou University,Zhengzhou,450000,China [3]Department of Rehabilitation MedicineⅢ,the First Affiliated Hospital of Zhengzhou University,Zhengzhou,450000,China [4]Department of Respiratory Medicine,the First Affiliated Hospital of Zhengzhou University,Zhengzhou,450000,China [5]Peabody College,Vanderbilt University,Nashville,TN,37240,USA [6]National Health Commission Key Laboratory of Prevention and Treatment of Cerebrovascular Diseases,Zhengzhou,450000,China

出　　处：《Chinese Journal of Integrative Medicine》2025年第3期261-269,共9页中国结合医学杂志(英文版)

基　　金：Supported by the National Health Commission Key Laboratory of Prevention and Treatment of Cerebrovascular Disease Grant(No.2020-PT310-01)。

摘　　要：Objective:To explore the effect of acupuncture therapy on dysphagia in patients with Parkinson's disease.Methods:This randomized controlled study lasted 42 days and included 112 patients with Parkinson's disease and dysphagia.Participants were randomly assigned to the experimental and control groups(56 cases each group)using the completely randomized design,all under routine treatment.The experimental group was given acupuncture therapy.The primary outcome was Penetration-Aspiration Scale(PAS).The secondary outcomes were(1)Standardized Swallowing Assessment(SSA),and(2)nutritional status including body mass index(BMI),serum albumin,prealbumin,and hemoglobin.Adverse events were recorded as safety indicators.Results:One participant quitted the study midway.There were no significant differences in baseline assessment(P>0.05).After treatment,both groups showed significant improvement in PAS,SSA and nutritional status except for BMI of the control group.There were significant differences between the two groups in the PAS for both paste and liquid,SSA(25.18±8.25 vs.20.84±6.92),BMI(19.97±3.34 kg/m^(2)vs.21.26±2.38 kg/m^(2)),serum albumin(35.16±5.29 g/L vs.37.24±3.98 g/L),prealbumin(248.33±27.72 mg/L vs.261.39±22.10 mg/L),hemoglobin(119.09±12.53 g/L vs.126.67±13.97 g/L)(P<0.05).There were no severe adverse events during the study.Conclusion:The combination of routine treatment and acupuncture therapy can better improve dysphagia and nutritional status in patients with Parkinson's disease,than routine treatment solely.(registration No.ClinicalTrial.gov NCT06199323)

关 键 词：ACUPUNCTURE Parkinson's disease DYSPHAGIA nutritional status 

分 类 号：R246.6[医药卫生—针灸推拿学]