Modular miniaturized synthesis and in situ biological evaluation facilitate rapid discovery of potent MraY inhibitors as antibacterial agents  

作　　者：Mianling Yang Meehyein Kim Peng Zhan 

机构地区：[1]Department of Medicinal Chemistry,Key Laboratory of Chemical Biology,Ministry of Education,School of Pharmaceutical Sciences,Shandong University,Ji'nan 250012,China [2]Infectious Diseases Therapeutic Research Center,Korea Research Institute of Chemical Technology(KRICT),Daejeon 34114,South Korea

出　　处：《Chinese Chemical Letters》2025年第2期1-3,共3页中国化学快报(英文版)

摘　　要：Despite the availability of effective antibacterial drugs,the increasing prevalence of antibiotic-resistant bacteria is primarily attributed to their excessive and inappropriate utilization.Antimicrobial resistance(AMR)represents one of the most concerning global health and development threats[1].Thereby,the continuous escalation in AMR necessitates urgent advancements in novel antibacterial strategies.The MraY enzyme,which plays a pivotal role in synthesizing bacterial cell wall-composing polysaccharides,holds significant potential as a target for antibacterial agents[2].However,its conformational dynamics have presented substantial challenges in developing MraY-targeting inhibitors.

关 键 词：holds SYNTHESIS attributed 

分 类 号：TQ460.1[化学工程—制药化工]