In situ formed fluorescent gold nanoclusters inhibit hair follicle regeneration in oxidative stress microenvironment via suppressing NFκB signal pathway  

作　　者：Xiangdong Lai Tengfei Liu Zengchao Guo Yihan Wang Jiang Xiao Qingxiu Xia Xiaohui Liu Hui Jiang Xuemei Wang 

机构地区：[1]State Key Laboratory of Digital Medical Engineering,School of Biological Science and Medical Engineering,Southeast University,Nanjing 210096,China

出　　处：《Chinese Chemical Letters》2025年第2期256-260,共5页中国化学快报(英文版)

基　　金：supported by the National Natural Science Foundation of China(Nos.82061148012,82027806,82372220,21974019);the National Key Research and Development Program of China(No.2017YFA0205300);the Primary Research&Development Plan of Jiangsu Province(No.BE2019716)。

摘　　要：Skins expose to kinds of risk factors for damage,such as the hormone drugs,skin care products and ultraviolet radiation,which is accompanied by the production of excessive reactive oxygen species(ROS)and eventually leads to hypertrichosis.This skin disease is not aesthetically pleasing and even causes psychological and spiritual problems such as inferiority,anxiety and irritability.Current therapies are limited and often unsatisfactory,such as pharmacological and physical therapies,which have adverse effects and cause the irreversible destruction of hair follicles.Gold nanoclusters have good biocompatibility and their biosynthesis in vivo is responsive to oxidative stress microenvironment(OSM),which could be a safe and effective drug for ROS-induced skin injury.In our study,we demonstrated that zero valence fluorescent gold nanoclusters(FGNCs)were in situ biosynthesized in the plucking-induced damaged skin but not in the normal skin after the administration of gold precursors(+3),while FGNCs inhibited hair follicle regeneration by negatively regulating nuclear transcription factor kappa B(NFκB)-mediated inflammatory response signaling pathway(NFκB/tumor necrosis factor-α(TNF-α)axis).This OSM-responsive in situ biosynthesis method is facile and safe and holds great promise for curing hypertrichosis associated with skin dermatitis and injury.

关 键 词：Fluorescent gold nanoclusters Skin injury Reactive oxygen species Hair follicle regeneration Oxidative stress microenvironment 

分 类 号：TB383.1[一般工业技术—材料科学与工程]