Strength through unity:Alkaline phosphatase-responsive AIEgen nanoprobe for aggregation-enhanced multi-mode imaging and photothermal therapy of metastatic prostate cancer  

作　　者：Ze Wang Hao Liang Annan Liu Xingchen Li Lin Guan Lei Li Liang He Andrew K.Whittaker Bai Yang Quan Lin 

机构地区：[1]State Key Laboratory of Supramolecular Structure and Materials,College of Chemistry,Jilin University,Changchun 130012,China [2]Department of Endocrinology,Lequn Branch,the First Hospital of Jilin University,Changchun 130021,China [3]Department of Urology,the First Hospital of Jilin University,Changchun 130021,China [4]Australian Institute for Bioengineering and Nanotechnology,the University of Queensland,Brisbane,QLD 4072,Australia

出　　处：《Chinese Chemical Letters》2025年第2期261-268,共8页中国化学快报(英文版)

基　　金：supported by Natural Science Foundation of Jilin Province(No.SKL202302002);Key Research and Development project of Jilin Provincial Science and Technology Department(No.20210204142YY);The Science and Technology Development Program of Jilin Province(No.2020122256JC);Beijing Kechuang Medical Development Foundation Fund of China(No.KC2023-JX-0186BQ079);Talent Reserve Program(TRP),the First Hospital of Jilin University(No.JDYY-TRP-2024007)。

摘　　要：Prostate cancer(PCa)is characterized by high incidence and propensity for easy metastasis,presenting significant challenges in clinical diagnosis and treatment.Tumor microenvironment(TME)-responsive nanomaterials provide a promising prospect for imaging-guided precision therapy.Considering that tumor-derived alkaline phosphatase(ALP)is over-expressed in metastatic PCa,it makes a great chance to develop a theranostics system with ALP responsive in the TME.Herein,an ALP-responsive aggregationinduced emission luminogens(AIEgens)nanoprobe AMNF self-assembly was designed for enhancing the diagnosis and treatment of metastatic PCa.The nanoprobe exhibited self-aggregation in the presence of ALP resulted in aggregation-induced fluorescence,and enhanced accumulation and prolonged retention period at the tumor site.In terms of detection,the fluorescence(FL)/computed tomography(CT)/magnetic resonance(MR)multi-mode imaging effect of nanoprobe was significantly improved post-aggregation,enabling precise diagnosis through the amalgamation of multiple imaging modes.Enhanced CT/MR imaging can achieve assist preoperative tumor diagnosis,and enhanced FL imaging technology can achieve“intraoperative visual navigation”,showing its potential application value in clinical tumor detection and surgical guidance.In terms of treatment,AMNF showed strong absorption in the near infrared region after aggregation,which improved the photothermal treatment effect.Overall,our work developed an effective aggregation-enhanced theranostic strategy for ALP-related cancers.

关 键 词：AIE Prostate cancer ALP responsive Enhanced multi-mode imaging Enhanced photothermal therapy 

分 类 号：O657.3[理学—分析化学] R737.25[理学—化学]