An ionic liquid functionalized sericin hydrogel for drug-resistant bacteria-infected diabetic wound healing  

作　　者：Jiajia Wang XinXin Ge Yajing Xiang Xiaoliang Qi Ying Li Hangbin Xu Erya Cai Chaofan Zhang Yulong Lan Xiaojing Chen Yizuo Shi Zhangping Li Jianliang Shen 

机构地区：[1]National Engineering Research Center of Ophthalmology and Optometry,Eye Hospital,Wenzhou Medical University,Wenzhou 325027,China [2]School of Chemical Engineering,Nanjing University of Science&Technology,Nanjing 210094,China [3]School&Hospital of Stomatology,Wenzhou Medical University,Wenzhou 325027,China [4]Zhejiang Engineering Research Center for Tissue Repair Materials,Wenzhou Institute,University of Chinese Academy of Sciences,Wenzhou 325001,China [5]The Quzhou Affiliated Hospital of Wenzhou Medical University,Quzhou People's Hospital,Quzhou 324000,China

出　　处：《Chinese Chemical Letters》2025年第2期279-285,共7页中国化学快报(英文版)

基　　金：supported by the National Natural Science Foundation of China(No.82372551)。

摘　　要：Diabetic wound healing is often complicated due to bacterial infections that intensify inflammation.Employing hydrogel dressings with inherent antibacterial properties can significantly reduce reliance on antibiotics for treating infected wounds in diabetics.Traditional hydrogels typically rely on the infiltration of bacteria into their porous structure to manifest antibacterial effects.However,this infiltration process is not only prolonged but can also exacerbate inflammation,further delaying the healing of the wound.Thus,promptly capturing and eliminating bacteria is crucial for enhancing the antibacterial efficiency of the hydrogel.In this context,we present a multifunctional hydrogel dressing,termed SIP,designed to tackle drug-resistant bacterial infections in diabetic wounds.This dressing integrates ionic liquid functional groups into a sericin-based matrix:phenylboronic acid for the immobilization of bacteria and imidazole for their subsequent annihilation.Expectedly,the SIP system demonstrates potent antibacterial activity against methicillin-resistant Staphylococcus aureus,verified through in vitro and in vivo experiments.As a result,SIP emerges as a promising candidate in the realm of hydrogel dressings with innate antibacterial properties,showcasing considerable potential for addressing diabetic wounds plagued by drug-resistant bacterial infections.

关 键 词：SERICIN Ionic liquids HYDROGELS Methicillin-resistant Staphylococcus aureus infection Diabetic wound healing 

分 类 号：R587.2[医药卫生—内分泌] TQ427.26[医药卫生—内科学]