The study of antibacterial activity of cationic poly(β-amino ester)regulating by amphiphilic balance  

作　　者：Chong Liu Ling Li Jiahui Gao Yanwei Li Nazhen Zhang Jing Zang Cong Liu Zhaopei Guo Yanhui Li Huayu Tian 

机构地区：[1]School of Materials Science and Engineering,Changchun University of Science and Technology,Changchun 130022,China [2]School of Materials Science and Engineering,Xiamen University of Technology,Xiamen 361024,China [3]College of Chemistry and Chemical Engineering,Xiamen University,Xiamen 361005,China [4]Key Laboratory of Polymer Ecomaterials,Changchun Institute of Applied Chemistry,Chinese Academy of Sciences,Changchun 130022,China

出　　处：《Chinese Chemical Letters》2025年第2期304-308,共5页中国化学快报(英文版)

基　　金：financially supported by the Natural Science Foundation of Jilin Province Science and Technology Department(No.20230101221JC);the National Natural Science Foundation of China(Nos.52173115,52073278,52203189);the Research Foundation for Advanced Talents of Xiamen University of Technology(Nos.5010423019,YKJ22052R)。

摘　　要：It is well known that cationic polymers have excellent antimicrobial capacity accompanied with high biotoxicity,to reduce biotoxicity needs to decrease the number of cationic groups on polymers,which will influence antimicrobial activity.It is necessary to design a cationic polymer mimic natural antimicrobial peptide with excellent antibacterial activity and low toxicity to solve the above dilemma.Here,we designed and prepared a series of cationic poly(β-amino ester)s(PBAEs)with different cationic contents,and introducing hydrophobic alkyl chain to adjust the balance between antimicrobial activity and biotoxicity to obtain an ideal antimicrobial polymer.The optimum one of synthesized PBAE(hydrophilic cationic monomer:hydrophobic monomer=5:5)was screened by testing cytotoxicity and minimum inhibitory concentration(MIC),which can effectively kill S.aureus and E.coli with PBAE concentration of15μg/m L by a spread plate bacteriostatic method and dead and alive staining test.The way of PBAE killing bacterial was destroying the membrane like natural antimicrobial peptide observed by scanning electron microscopy(SEM).In addition,PBAE did not exhibit hemolysis and cytotoxicity.In particular,from the result of animal tests,the PBAE was able to promote healing of infected wounds from removing mature S.aureus and E.coli on the surface of infected wound.As a result,our work offers a viable approach for designing antimicrobial materials,highlighting the significant potential of PBAE polymers in the field of biomedical materials.

关 键 词：Antimicrobial Cationic polymers Poly(β-amino ester)s Michael addition polymerization Amphiphilic balance 

分 类 号：TQ317[化学工程—高聚物工业]