NIR driven catalytic enhanced acute lung injury therapy by using polydopamine@Co nanozyme via scavenging ROS  

作　　者：Xiaoshuai Wu Bailei Wang Yichen Li Xiaoxuan Guan Mingjing Yin Wenquan Lv Yin Chen Fei Lu Tao Qin Huyang Gao Weiqian Jin Yifu Huang Cuiping Li Ming Gao Junyu Lu 

机构地区：[1]Intensive Care Unit,The Second Affiliated Hospital of Guangxi Medical University,Nanning 530007,China [2]Department of Critical Care Medicine,The Ninth Affiliated Hospital of Guangxi Medical University,Beihai 536000,China [3]Life Sciences Institute,Guangxi Medical University,Nanning 530021,China [4]Department of Emergency,The First Affiliated Hospital of Guangxi Medical University,Nanning 530021,China [5]College&Hospital of Stomatology,Guangxi Medical University,Nanning 530021,China [6]Guangxi Key Laboratory of Oral and Maxillofacial Rehabilitation and Reconstruction,Guangxi Medical University,Nanning 530021,China

出　　处：《Chinese Chemical Letters》2025年第2期309-315,共7页中国化学快报(英文版)

基　　金：financially supported by the Key Research&Development Program of Guangxi(No.GuiKeAB22080088);the Joint Project on Regional High-Incidence Diseases Research of Guangxi Natural Science Foundation(No.2023GXNSFDA026023);the Natural Science Foundation of Guangxi(No.2023JJA140322);the National Natural Science Foundation of China(No.82360372);the High-level Medical Expert Training Program of Guangxi“139 Plan Funding(No.G202003010);the Medical Appropriate Technology Development and Popularization and Application Project of Guangxi(No.S2020099)。

摘　　要：Acute lung injury(ALI)was characterized by excessive reactive oxygen species(ROS)levels and inflammatory response in the lung.Scavenging ROS could inhibit the excessive inflammatory response,further treating ALI.Herein,we designed a novel nanozyme(P@Co)comprised of polydopamine(PDA)nanoparticles(NPs)loading with ultra-small Co,combining with near infrared(NIR)irradiation,which could efficiently scavenge intracellular ROS and suppress inflammatory responses against ALI.For lipopolysaccharide(LPS)induced macrophages,P@Co+NIR presented excellent antioxidant and anti-inflammatory capacities through lowering intracellular ROS levels,decreasing the expression levels of interleukin-6(IL-6)and tumor necrosis factor-α(TNF-α)as well as inducing macrophage M2 directional polarization.Significantly,it displayed the outstanding activities of lowering acute lung inflammation,relieving diffuse alveolar damage,and up-regulating heat shock protein 70(HSP70)expression,resulting in synergistic enhanced ALI therapy effect.It offers a novel strategy for the clinical treatment of ROS related diseases.

关 键 词：Acute lung injury NIR driven Nanozyme ROS scavenging M2 directional polarization 

分 类 号：TB383.1[一般工业技术—材料科学与工程] R563[医药卫生—呼吸系统]