Swelling and erosion assisted sustained release of tea polyphenol from antibacterial ultrahigh molecular weight polyethylene for joint replacement  

作　　者：Yue Ren Kang Li Yi-Zi Wang Shao-Peng Zhao Shu-Min Pan Haojie Fu Mengfan Jing Yaming Wang Fengyuan Yang Chuntai Liu 

机构地区：[1]State Key Laboratory of Structural Analysis,Optimization and CAE Software for Industrial Equipment,National Engineering Research Center for Advanced Polymer Processing Technology,Zhengzhou University,Zhengzhou 450002,China [2]Tianjian Laboratory of Advanced Biomedical Sciences,Academy of Medical Sciences,Zhengzhou University,Zhengzhou 450000,China [3]Department of Stomatology,The First Affiliated Hospital of Zhengzhou University,Zhengzhou 450000,China

出　　处：《Chinese Chemical Letters》2025年第2期316-320,共5页中国化学快报(英文版)

基　　金：the National Natural Science Foundation of China(No.5220031085);the Postdoctoral Research Project in Henan Province(No.HN2022054);the Key Scientific Research Projects of Colleges and Universities in Henan Province(No.23A430009);the State Key Laboratory of Polymer Materials Engineering(No.sklpme2022-4-03);the Key Technologies R&D Program of Henan Province(No.242102230131)。

摘　　要：The considerable hazard posed by periprosthetic joint infections underlines the urgent need for the rapid advancement of in-situ drug delivery systems within joint materials.However,the pursuit of sustained antibacterial efficacy remains a formidable challenge.In this context,we proposed a novel strategy that leverages swelling and erosion mechanisms to facilitate drug release of drug-loaded ultrahigh molecular weight polyethylene(UHMWPE),thereby ensuring its long-lasting antibacterial performance.Polyethylene oxide(PEO),a hydrophilic polymer with fast hydrating ability and high swelling capacity,was incorporated in UHMWPE alongside the antibacterial tea polyphenol(epigallocatechin gallate,EGCG as representative).The swelling of PEO enhanced water infiltration into the matrix,while the erosion of PEO balanced the release of the encapsulated EGCG,resulting in a steady release.The behavior was supported by the EGCG release profiles and the corresponding fitted release kinetic models.As demonstrated by segmented antibacterial assessments,the antibacterial efficiency was enhanced 2to 3 times in the PEO/EGCG/UHMWPE composite compared to that of EGCG/UHMWPE.Additionally,the PEO/EGCG/UHMWPE composite exhibited favorable biocompatibility and mechanical performance,making it a potential candidate for the development of drug-releasing joint implants to combat prosthetic bacterial infections.

关 键 词：Tea polyphenol ANTIBACTERIAL PEO UHMWPE Joint replacement 

分 类 号：R687.4[医药卫生—骨科学] TQ325.12[医药卫生—外科学] TB332[医药卫生—临床医学]