Multiphoton photoredox catalysis enables selective hydrodefluorinations  

作　　者：Jiaqi Jia Kathiravan Murugesan Chen Zhu Huifeng Yue Shao-Chi Lee Magnus Rueping 

机构地区：[1]KAUST Catalysis Center,KCC,King Abdullah University of Science and Technology,KAUST,Thuwal 23955-6900,Saudi Arabia

出　　处：《Chinese Chemical Letters》2025年第2期338-344,共7页中国化学快报(英文版)

摘　　要：Late-stage modification of complex molecules via site-selective hydrodefluorination is a challenging endeavor.The selective activation of carbon-fluorine(C-F) bonds in the presence of multiple C-F bonds is of importance in organic synthesis and drug discovery.Herein,we describe the activation of C-F bonds via multiphoton photoredox catalysis to selectively produces a series of hydrodefluorinated compounds by simply tuning the reaction conditions.Moreover,this protocol was successfully applied to the late-stage functionalization of different drug-derivatives and the corresponding mono-,di-,and tri-defluorinated products were obtained in good to excellent yields.A detailed mechanistic investigation provides insight into the unprecedented hydrodefluorination pathway.

关 键 词：Photoredox catalysis C-F bond activation SITE-SELECTIVITY MULTIPHOTON Trifluoroacetamide 

分 类 号：O643.36[理学—物理化学] O644.1[理学—化学]