Nanoplastics and nano-ZnO facilitate Cd accumulation in zebrafish larvae via a distinct pathway:Revelation by LA-ICP-MS imaging  

作　　者：Pengyu Chen Beibei Chen Man He Yuxi Zhou Lei Lei Jian Han Bingsheng Zhou Ligang Hu Bin Hu 

机构地区：[1]Department of Chemistry,Wuhan University,Wuhan 430072,China [2]State Key Laboratory of Freshwater Ecology and Biotechnology,Institute of Hydrobiology,Chinese Academy of Sciences,Wuhan 430072,China [3]State Key Laboratory of Environmental Chemistry and Ecotoxicology,Research Center for Eco-Environmental Sciences,Chinese Academy of Sciences,Beijing 100085,China

出　　处：《Chinese Chemical Letters》2025年第2期408-412,共5页中国化学快报(英文版)

基　　金：financially supported by the National Natural Science Foundation of China(NSFC,Nos.22174103 and 21575107)。

摘　　要：The interaction between nanoparticles (NPs) and pollutants affects their bioavailability and toxicity.However,the processes by which NPs and pollutants change in vivo have rarely been explored.Here,using laser ablation-inductively coupled plasma-mass spectrometry (LA-ICP-MS),we found that both nanoplastics and ZnO NPs caused more Cd to accumulate in zebrafish larvae,but with distinct pathways.Nanoplastics could adsorb Cd^(2+) and transfer it into the larvae through the“Trojan horse”effect.The coexposure of nanoplastics and Cd^(2+) caused Cd to accumulate in the abdomen where the nanoplastics were located without dissociation,showing a lower toxic effect than Cd^(2+) exposure alone.ZnO NPs weakly adsorbed Cd^(2+),but they increased the Zn and Cd contents in larvae by enhancing the expression of metal transporters.The coexposure of ZnO and Cd^(2+) evenly distributed Cd in the larvae,revealing a more severe toxic effect than Cd^(2+) exposure alone.Our results demonstrated the changing bioavailability and toxicity of Cd induced by different NPs.This also shows the vital role LA-ICP-MS plays in revealing the relationship between toxicity and bioavailability.In addition,the long-term effect of bioavailability on heavy metal toxicity and nanosafety deserves further investigation.

关 键 词：LA-ICP-MS Nanoplastics ZnO nanoparticles CADMIUM Combined effect Zebrafish larvae 

分 类 号：X835[环境科学与工程—环境工程] O657.63[理学—分析化学]