Tracing molecular margins of lung cancer by internal extractive electrospray ionization mass spectrometry  

作　　者：Haiyan Lu Jiayue Ye Yiping Wei Hua Zhang Konstantin Chingin Vladimir Frankevich Huanwen Chen 

机构地区：[1]State Key Laboratory of Inorganic Synthesis and Preparative Chemistry,College of Chemistry,Jilin University,Changchun 130012,China [2]Jiangxi Key Laboratory for Mass Spectrometry and Instrumentation,East China University of Technology,Nanchang 330013,China [3]The Second Affiliated Hospital of Nanchang University,Nanchang 330006,China [4]School of Pharmacy,Jiangxi University of Chinese Medicine,Nanchang 330004,China [5]National Medical Research Center for Obstetrics,Gynecology and Perinatology named after Academician V.I.Kulakov of Ministry of Healthcare of Russian Federation,Moscow 117997,Russian Federation

出　　处：《Chinese Chemical Letters》2025年第2期465-469,共5页中国化学快报(英文版)

基　　金：supported by Jiangxi Provincial International Science and Technology Cooperation Project(Nos.20203BDH80W010 and 20232BBH80012);the National Natural Science Foundation of China(Nos.82160410 and 81860379);Foundation of Jiangxi Provincial Department of Science and Technology(No.20212ACB206018);Key Research and Development Program of Jiangxi Province(No.20223BBG71009)。

摘　　要：Accurate determination of lung cancer margins at the molecular level is of great significance to determine the optimal extent of resection during surgical operation and reduce the risk of postoperative recurrence.In this study,internal extractive electrospray ionization mass spectrometry(i EESI-MS)was used to trace potential molecular tumor margins in lung cancer tissue.Molecular differential model for the determination of lung cancer tumor margin was established via partial least-squares discriminant analysis(PLS-DA)of iEESI-MS data collected from lung tissue pieces within cancer tumor area and iEESI-MS data collected from lung tissue pieces outside cancer tumor area.Proof-of-concept data demonstrate that the developed molecular differential model yields ca.1-2 mm wider potential molecular tumor margin of a lung cancer compared to the conventional histological analysis,showing promising potential of iEESI-MS to increase the accuracy of tumor margins determination and lower risk of lung cancer postoperative recurrence.Furthermore,our results revealed that creatine and taurine showed positive correlations with lung cancer.

关 键 词：Lung cancer Tumor margins Internal extractive electrospray ionization Mouse models Postoperative recurrence 

分 类 号：O657.63[理学—分析化学] R734.2[理学—化学]