血浆6-Keto-PGF1α和血清AQP-4水平与高血压脑出血患者微创术后脑水肿及预后的相关性  

Correlation of plasma 6-Keto-PGF1αand serum AQP-4 levels with brain edema and prognosis in hypertensive intracerebral hemorrhage patients after minimally invasive surgery

作　　者：赵淑云 王子未 郑颖[2] 谢星 田丽 ZHAO Shu-yun;WANG Zi-wei;ZHENG Ying(Department of Neurosurgery,Xingtai Central Hospital,Xingtai Hebei 054000,China;Clinical College,Hebei Medical University,Shijiazhuang Hebei 050000,China)

机构地区：[1]邢台市中心医院神经外科,河北邢台054000 [2]河北医科大学临床学院,河北石家庄050000

出　　处：《临床和实验医学杂志》2025年第4期351-355,共5页Journal of Clinical and Experimental Medicine

基　　金：河北省2023年度医学科学研究课题计划(编号:20231460)。

摘　　要：目的探究血浆6-酮-前列腺素F1α(6-Keto-PGF1α)和血清水通道蛋白4(AQP-4)水平与高血压脑出血患者微创术后脑水肿及预后的相关性。方法回顾性选取2022年2月至2024年2月邢台市中心医院收治的高血压脑出血患者120例,所有患者均接受微创手术治疗,采用格拉斯哥预后评分(GOS)评估患者的预后情况,并将GOS评分<4分的44例患者纳入预后不良组,GOS评分≥4分的76例患者纳入预后良好组。比较组间临床资料(包括性别、年龄、体重指数、病程、收缩压、舒张压、空腹血糖、出血量、出血部位、合并糖尿病、合并冠心病、合并肺部疾病及发病至入院时间),并分析患者的血脂指标[总胆固醇、甘油三酯、低密度脂蛋白胆固醇(LDL-C)和高密度脂蛋白胆固醇(HDL-C)]及血浆6-Keto-PGF1α、血清AQP-4水平差异,观察患者血浆6-Keto-PGF1α和血清AQP-4水平与其不同出血量、脑水肿程度的关联,并探究其对患者预后不良的预测效能。结果预后不良组和预后良好组组间的性别、体重指数、病程、收缩压、舒张压、空腹血糖、出血量、出血部位、合并糖尿病、合并冠心病、合并肺部疾病及发病至入院时间比较,差异均无统计学意义(P>0.05);预后不良组平均年龄为(68.11±8.15)岁,高于预后良好组[(62.11±7.11)岁],差异有统计学意义(P<0.05)。两组血脂指标比较,差异均无统计学意义(P>0.05)。预后不良组的血浆6-Keto-PGF1α水平为(11.23±2.12)pg/mL,低于预后良好组[(15.55±2.31)pg/mL],血清AQP-4水平为(88.46±9.45)u/mL,高于预后良好组[(33.16±7.44)u/mL],差异均有统计学意义(P<0.05)。在不同出血量的患者中,其血浆6-Keto-PGF1α、血清AQP-4水平差异均无统计学意义(P>0.05)。轻中度脑水肿患者的血浆6-Keto-PGF1α水平为(15.64±2.46)pg/mL,高于重度脑水肿患者[(12.66±1.98)pg/mL],血清AQP-4水平为(44.89±12.01)u/mL,低于重度脑水肿患者[(86.46±11.15)u/mL],差异均有�Objective To investigate the correlation of plasma 6-ketone-prostaglandin F1α(6-Keto-PGF1α)and serum aquaporin-4(AQP-4)levels with brain edema and prognosis in patients with hypertensive intracerebral hemorrhage after minimally invasive surgery.Methods A retrospective study was conducted on 120 patients with hypertensive intracerebral hemorrhage in Xingtai Central Hospital from February 2022 to February 2024.All patients received minimally invasive surgical treatment.The Glasgow outcome scale(GOS)score was used to evaluate the prognosis of patients.Forty-four patients with a GOS score<4 were included in the poor prognosis group,and the other 76 patients were included in the good prognosis group.The clinical data between the groups(including gender,age,body mass index,course of disease,systolic blood pressure,diastolic blood pressure,fasting blood glucose,blood loss,bleeding site,diabetes mellitus,coronary heart disease,pulmonary disease and time from onset to admission)were compared,and the differences in lipid indexes[total cholesterol,triglycerides,low-density lipoprotein cholesterol(LDL-C)and high-density lipoprotein cholesterol(HDL-C)]and the levels of plasma 6-Keto-PGF1αand serum AQP-4 were analyzed.The associations between the levels of plasma 6-Keto-PGF1αand serum AQP-4 and different amount of bleeding,brain edema degree were observed,and their predictive efficacy for poor prognosis in patients was explored.Results There was no statistically significant difference in gender,body mass index,course of disease,systolic blood pressure,diastolic blood pressure,fasting blood glucose,blood loss,bleeding site,diabetes mellitus,coronary heart disease,pulmonary disease and time from onset to admission between the poor prognosis group and the good prognosis group(P>0.05);the average age of the poor prognosis group was(68.11±8.15)years,which was higher than that of the good prognosis group[(62.11±7.11)years],and the difference was statistically significant(P<0.05).There were no statistically significant differen

关 键 词：颅内出血 高血压性 脑水肿 6-酮-前列腺素F1Α 水通道蛋白质4 预后 

分 类 号：R651.1[医药卫生—外科学]