超声造影定量参数结合血清VEGF-C、CA125预测卵巢癌患者发生淋巴结转移的价值  

Predictive value of quantitative parameters of contrast-enhanced ultrasound combined with serum VEGF-C and CA125 in lymphatic metastasis in patients with ovarian cancer

作　　者：郭艳菊 江国露 周锋 董静 王志群 GUO Yan-ju;JIANG Guo-lu;ZHOU Feng(Department of Physical Examination,Electric Power Teaching Hospital,Capital Medical University,Beijing 100073,China)

机构地区：[1]首都医科大学电力教学医院体检科,北京100073 [2]康复大学青岛中心医院检验科,山东青岛266042

出　　处：《临床和实验医学杂志》2025年第4期435-438,共4页Journal of Clinical and Experimental Medicine

基　　金：北京市卫生健康委员会项目(编号:京-2022-10)。

摘　　要：目的探讨超声造影定量参数结合血清血管内皮生长因子C(VEGF-C)、糖类抗原125(CA125)预测卵巢癌患者发生淋巴结转移的价值。方法回顾性纳入2020年2月至2022年6月康复大学青岛中心医院接收的112例卵巢癌患者,根据是否存在淋巴结转移,将其分为未转移组(n=62)和转移组(n=50)。比较两组超声造影定量参数(基础强度、达峰时间、峰值强度、增强强度、到达时间);比较两组血清VEGF-C、CA125表达水平。采用多因素Logistics回归分析影响卵巢癌患者发生淋巴结转移的因素;采用受试者操作特征(ROC)曲线评估卵巢癌患者发生淋巴结转移的预测价值。结果转移组的基础强度和达峰时间分别为(12.25±1.23)dB、(27.23±2.12)s,均低于未转移组[(15.21±2.18)dB、(30.98±2.54)s],差异均有统计学意义(P<0.05);两组间峰值强度、增强强度、到达时间比较,差异均无统计学意义(P>0.05)。转移组患者血清VEGF-C、CA125的表达水平分别为(157.52±16.36)pg/mL、(42.52±5.18)U/mL,高于未转移组[(132.24±14.18)pg/mL、(33.34±5.12)U/mL],差异均有统计学意义(P<0.05)。多因素Logistic回归分析结果显示,基础强度、达峰时间、CA125、VEGF-C水平均是影响卵巢癌患者发生淋巴结转移的因素(P<0.05)。超声造影定量参数联合血清VEGF-C、CA125对卵巢癌患者发生淋巴结转移预测的曲线下面积(AUC)为0.989,显著高于基础强度、达峰时间、血清VEGF-C及血清CA125单独检测(P<0.05)。结论血清VEGF-C、CA125在卵巢癌患者发生淋巴结转移患者中水平升高,而超声造影定量参数联合血清VEGF-C、CA125检测对卵巢癌患者发生淋巴结转移具有更高的预测价值。Objective To investigate the value of quantitative parameters of contrast-enhanced ultrasound combined with serum vascular endothelial growth factor C(VEGF-C)and carbohydrate antigen 125(CA125)in predicting lymphatic metastasis in patients with ovarian cancer.Methods A total of 112 patients with ovarian cancer admitted to the Rehabilitation University Qingdao Central Hospital from February 2020 to June 2022 were retrospectively included.According to the presence or absence of lymphatic metastasis,they were divided into the non-metastasis group(n=62)and the metastasis group(n=50).The quantitative parameters of contrast-enhanced ultrasound(baseline intensity,peak time,peak strength,enhancement strength and arrival time)were compared between the two groups.The expression levels of serum VEGF-C and CA125 were compared between the two groups.The factors affecting lymph node metastasis in patients with ovarian cancer was analyzed using multivariate Logistics regression analysis.The predictive value of lymph node metastasis in patients with ovarian cancer was evaluated using the receiver operating characteristic(ROC)curve.Results The baseline intensity and peak time of the metastasis group were(12.25±1.23)dB and(27.23±2.12)s,respectively,which were lower than those of the non-metastasis group[(15.21±2.18)dB and(30.98±2.54)s],the differences were statistically significant(P<0.05);there were no statistically significant differences in peak intensity,enhanced intensity and arrival time between the two groups(P>0.05).The expression levels of serum VEGF-C and CA125 in the metastasis group were(157.52±16.36)pg/mL and(42.52±5.18)U/mL,respectively,which were higher than those in the non-metastasis group[(132.24±14.18)pg/mL,(33.34±5.12)U/mL],the differences were statistically significant(P<0.05).Multivariate Logistic regression analysis showed that basal intensity,peak time,CA125 and VEGF-C levels were all factors affecting lymph node metastasis in patients with ovarian cancer(P<0.05).The area under the curve(AUC)of ultr

关 键 词：卵巢肿瘤 淋巴结转移 超声造影 血管内皮生长因子C 糖类抗原125 预测价值 

分 类 号：R445.1[医药卫生—影像医学与核医学] R737.31[医药卫生—诊断学]