清肺化痰方联合氨溴索治疗慢性支气管炎急性发作(痰热壅肺证)的疗效及对炎性因子指标的影响  

Efficacy of Qingfei Huatan decoction combined with ambroxol in the treatment of acute exacerbation of chronic bronchitis(phlegm-heat obstructing the lung syndrome)and its effects on inflammatory factor indicators

作　　者：李泽瀚 石海莎 LI Zehan;SHI Haisha(Department of Emergency,He’nan Electric Power Hospital,Zhengzhou 450003,China;Department of Pediatrics,the Third People’s Hospital of He’nan Province,Zhengzhou 450000,China)

机构地区：[1]河南电力医院急诊科,郑州450003 [2]河南省直第三人民医院儿科,郑州450000

出　　处：《上海医药》2025年第1期39-42,共4页Shanghai Medical & Pharmaceutical Journal

摘　　要：目的:探讨清肺化痰方联合氨溴索治疗慢性支气管炎急性发作(痰热壅肺证)的疗效。方法:将100例慢性支气管炎急性发作(痰热壅肺证)患者随机分为对照组和观察组,各50例。对照组予西药治疗,观察组联合清肺化痰方治疗。比较两组临床指标恢复时间、肺功能、血清炎性因子水平及临床疗效,记录不良反应。结果:治疗后,观察组临床指标恢复时间和白介素-6、白介素-8、C反应蛋白水平低于对照组,用力肺活量、第1秒用力呼气容积、呼气峰值流速及治疗总有效率高于对照组(P<0.05);两组均未发生不良反应。结论:清肺化痰方治疗慢性支气管炎急性发作(痰热壅肺证)效果明显,能够抑制炎症反应,提高肺功能。未来应研究这种治疗的长期疗效和潜在机制。Objective:To investigate the efficacy of Qingfei Huatan decoction combined with ambroxol in the treatment of patients with acute exacerbation of chronic bronchitis(phlegm-heat obstructing the lung syndrome).Methods:One hundred of the patients were randomly allocated to either a control group or an observation group with 50 cases each.The control group received conventional Western medicine treatment,while the observation group was treated with Qingfei Huatan decoction combined with Western medicine.The outcomes assessed included clinical recovery time,lung function,serum inflammatory factor levels,clinical efficacy rates and incidence of adverse reactions in both groups.Results:After treatment,the observation group showed shorter clinical recovery time and lower levels of interleukin 6,interleukin 8,and C-reactive protein compared to the control group.Additionally,the observation group also showed significantly improved lung function parameters(forced vital capacity,forced expiratory volume in one second,peak expiratory flow),higher clinical efficacy rates(P<0.05)compared to the control group(P<0.05).No adverse reactions occurred in either group.Conclusion:Qingfei Huatan decoction can significantly improves outcomes in acute exacerbation of chronic bronchitis(phlegm-heat obstructing the lung syndrome)by suppressing inflammatory responses and enhancing lung function.Future studies should investigate the long-term efficacy and underlying mechanisms of this treatment.

关 键 词：清肺化痰方 慢性支气管炎急性发作 痰热壅肺证 炎性因子 肺功能 

分 类 号：R289.5[医药卫生—方剂学] R562.21[医药卫生—中药学]