鼻窦-眼眶孤立性侵袭性曲霉菌病的现状与研究进展  

Current status and research progress of nasal sinus-orbit isolated invasive aspergillosis

作　　者：陈兰兰 张纪帅 CHEN Lanlan;ZHANG Jishuai(Department of Ophthalmology,Guagndong Provincial Hospital of Traditional Chinese Medicine,Hainan Hospital/Hainan Traditional Chinese Medicine Hospital,Haikou,Hainan,570100,China;Department of Otorhinology,The 928th Hospital of the Joint Logistics Support Force,Haikou,Hainan,570100,China)

机构地区：[1]广东省中医院海南医院/海南省中医院眼科,海南海口570100 [2]联勤保障部队第928医院五官科,海南海口570100

出　　处：《当代医学》2024年第25期185-189,共5页Contemporary Medicine

基　　金：联勤保障部队第九二八医院人才培育项目。

摘　　要：鼻窦-眼眶孤立性侵袭性曲霉菌病的发病率相对较低,其感染通常起源于副鼻窦。当机体免疫防御功能下降时,真菌可趁势侵犯眼眶。眼眶是真菌向颅内进一步侵犯的途径,一旦中枢神经系统感染,患者预后较差,病死率可达40%~80%。该病临床症状变化多样,也缺乏特征性的影像学特点,临床诊疗中易误诊为其他疾病,如特发性眼眶炎症、眶蜂窝织炎、眼眶肿瘤等,导致病情延误,错过最佳治疗时间。本文对鼻窦-眼眶孤立性侵袭性曲霉菌病的临床特征、影像学表现及治疗手段等作一综述,以期加强临床医师对该病的重视及认识,尽早诊断和及时治疗该病。The incidence of nasal sinus-orbital isolated invasive aspergillosis is relatively low,and infections often originate from the paranasal sinuses.When the function of immune system declines,the fungus can invade the orbit.The orbit is the way for fungi to further invade the intracranial,once the central nervous system is infected,the prognosis of patients is poor,and the fatality rate can reach 40%-80%.The clinical changes of the disease are diverse,lacking of characteristic imaging characteristics,it can be easily misdiagnosed as other diseases such as idiopathic orbital in-flammation,orbital cellulitis,orbital tumors,etc,missing the best time for treatment.The article reviews the clinical characteristics,imaging manifes-tations and treatment methods of nasal sinus-orbital isolated invasive aspergillosis,in order to strengthen clinicians'attention to and understanding of the disease,early diagnosis and timely treatment of the disease.

关 键 词：眼眶 曲霉菌病 抗真菌治疗 

分 类 号：R519[医药卫生—内科学]