基于传舍理论及肿瘤微环境论治结直肠癌肝转移  

Treatment of Colorectal Cancer Liver Metastasis based on Chuanshe Theory and Tumor Microenvironment Theory

作　　者：徐勤 谷珍珍 吴娇 连花 吴煜[2] XU Qin;GU Zhenzhen;WU Jiao;LIAN Hua;WU Yu(Graduate School of Beijing University of Chinese Medicine,Beijing China 100029;Xiyuan Hospital Affiliated to China Academy of Chinese Medical Sciences,Beijing China 100091)

机构地区：[1]北京中医药大学研究生院,北京100029 [2]中国中医科学院西苑医院,北京100091

出　　处：《中医学报》2025年第3期488-492,共5页Acta Chinese Medicine

基　　金：国家重点研发计划项目(2017YFC1700606);中国中医科学院科技创新工程项目(CI2021A01803)。

摘　　要：结直肠癌肝转移(colorectal cancer liver metastasis,CRC-LM)的基本途径是“传舍”,癌毒流传扩散,留舍停积,形成转移瘤。脾虚痰凝、气机失和、肝血不足分别是CRC-LM过程中癌毒滋生、流传、留舍的主要病机。肿瘤微环境(tumor microenvironment,TME)是结直肠癌(colorectal cancer,CRC)细胞发生发展的必要环境。脾虚痰凝、气机失和、肝血不足等中医病理状态所形成的免疫异常、炎性反应、缺氧环境以及酸性微环境,这三者之间相互影响、相互作用,最终共同构成了一个复杂的TME,从而助长了肿瘤的生长和转移。因此,健脾化痰、调畅气机、疏肝养血是防治CRC-LM的主要原则。The basic pathway of colorectal cancer liver metastasis(CRC-LM)is"Chuanshe",in which the cancerous toxin spreads and stagnates to form metastatic tumor.Spleen deficiency and Phlegm coagulation,Qi disharmony,and Liver blood deficiency are the main pathways for the growth,spread and retention of cancer Toxin in the process of CRC-LM,respectively.Tumor microenvironment(TME)is the necessary environment for the development of colorectal cancer(CRC)cells.The immune abnormality,inflammatory reaction,hypoxic environment,and acidic microenvironment,which are formed by the pathological states in Chinese medicine,such as Spleen deficiency and Phlegm coagulation,Qi disharmony,and Liver blood insufficiency,interact with each other,and ultimately constitute a complex TME,which contributes to the growth and metastasis of tumors.Therefore,strengthening Spleen and resolving Phlegm,regulating Qi,dredging Liver and nourishing blood are the main principles for the prevention and treatment of CRC-LM.

关 键 词：结直肠癌肝转移 肿瘤微环境 传舍理论 脾虚痰凝 气机失和 肝血不足 

分 类 号：R273.357[医药卫生—中西医结合]