布鲁氏菌Ⅳ型分泌系统效应因子调控宿主细胞功能研究进展  

Progress in the regulation of host cell functions by Brucella typeⅣsecretion system effectors

作　　者：张孟涛 戴恩慧 孙东杰 赵彦骁 丁家波[1,2] ZHANG Mengtao;DAI Enhui;SUN Dongjie;ZHAO Yanxiao;DING Jiabo(Institute of Animal Sciences,Chinese Academy of Agricultural Sciences,Beijing 100193,China;Key Laboratory of Animal Biosafety Risk Prevention and Control(North)of MARA,Beijing 100193,China;College of Animal Science and Veterinary Medicine,Shandong Agricultural University,Tai’an 271018,Shandong,China)

机构地区：[1]中国农业科学院北京畜牧兽医研究所,北京100193 [2]农业农村部动物生物安全风险预警及防控重点实验室(北方),北京100193 [3]山东农业大学动物科技学院,山东泰安271018

出　　处：《微生物学通报》2025年第2期533-544,共12页Microbiology China

基　　金：中国农业科学院科技创新工程(CAAS-CSLPDCP-202403)。

摘　　要：布鲁氏菌(Brucella)是一种全球广泛传播的人畜共患病原体,能够感染野生动物、家养动物及人类。为了在宿主体内建立并维持慢性感染,布鲁氏菌进化出了多种策略逃逸宿主的免疫应答机制,并且在细胞内大量繁殖。其核心机制主要依赖于Ⅳ型分泌系统(typeⅣsecretion system,T4SS)及其分泌的效应因子。T4SS通过将效应因子直接注入宿主细胞内,调控宿主细胞的多种功能,从而帮助病原体逃避免疫监控、操纵宿主细胞内环境,并促进布鲁氏菌的生存与复制。本文综述了布鲁氏菌T4SS的结构与功能,以及T4SS效应因子在调控宿主细胞功能方面的最新研究进展,探讨了布鲁氏菌如何通过调节宿主细胞信号传导途径,实现对细胞内液泡的控制,并形成有利于细菌存活的复制生态位。这些研究进展为我们更好地理解布鲁氏菌感染的致病机制提供了新见解,并有助于开发更有效的预防和治疗策略来应对布鲁氏菌感染。Brucella is a genus of globally widespread zoonotic pathogens capable of infecting wild animals,domestic animals,and humans.To establish and sustain chronic infections within the host,Brucella have evolved multiple strategies to evade host immune responses and extensively replicate in host cells,which primarily rely on the typeⅣsecretion system(T4SS)and its secreted effectors.The T4SS functions by directly injecting effectors into host cells,modulating various host cell functions to help the pathogen evade immune surveillance,manipulate the intracellular environment,and promote its survival and replication.This article reviews the structure and function of the Brucella T4SS and the latest research progress in the role of Brucella T4SS effectors in regulating host cell functions,exploring how bacteria of Brucella manipulate host cell signaling pathways to control intracellular vacuole dynamics and establish a replicative niche conducive to bacterial survival.These advancements provide new insights into the pathogenesis of Brucella infections and aid in the development of more effective strategies for preventing and treating Brucella-related diseases.

关 键 词：布鲁氏菌 Ⅳ型分泌系统 效应因子 功能调控 

分 类 号：S852.61[农业科学—基础兽医学] R378[农业科学—兽医学]